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  NGF serum levels are associated with regional gray matter volume differences in schizophrenia patients

Neugebauer, K., Hammans, C., Wensing, T., Kumar, V., Grodd, W., Mevissen, L., et al. (2019). NGF serum levels are associated with regional gray matter volume differences in schizophrenia patients. Frontiers in Psychiatry, 10: 275, pp. 1-14. doi:10.3389/fpsyt.2019.00275.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6E49-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-99D0-5
Genre: Journal Article

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 Creators:
Neugebauer, K, Author
Hammans, C, Author
Wensing, T, Author
Kumar, V1, 2, Author              
Grodd, W1, 2, Author              
Mevissen, L, Author
Sternkopf, MA, Author
Novakovic, A, Author
Abel, T, Author
Habel, U, Author
Nickl-Jockschat, T, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Numerous neuroimaging studies have revealed structural brain abnormalities in schizophrenia patients. There is emerging evidence that dysfunctional nerve growth factor (NGF) signaling may contribute to structural brain alterations found in these patients. In this pilot study, we investigated whether there was a correlation between NGF serum levels and gray matter volume (GMV) in schizophrenia patients. Further, we investigated whether there was an overlap between the correlative findings and cross-sectional GMV differences between schizophrenia patients and healthy controls. Serum NGF was significantly correlated to GMV in the left prefrontal lobe, the left midcingulate cortex and the brainstem in schizophrenia patients. However, we did not find any correlations of NGF serum levels with GMV in healthy controls. Schizophrenia patients showed smaller GMV than healthy controls in brain regions located in the bilateral limbic system, bilateral parietal lobe, bilateral insula, bilateral primary auditory cortex, left frontal lobe and bilateral occipital regions. In a conjunction analysis, GMV in the left midcingulate cortex (MCC) appears negatively correlated to NGF serum levels in the group of schizophrenia patients and also to be reduced compared to healthy controls. These results suggest an increased vulnerability of schizophrenia patients to changes in NGF levels compared to healthy controls and support a role for NGF signaling in the pathophysiology of schizophrenia.

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 Dates: 2019-04
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.3389/fpsyt.2019.00275
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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 275 Start / End Page: 1 - 14 Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640