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  A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits

Snoek, B. L., Volkers, R. J. M., Nijveen, H., Petersen, C., Dirksen, P., Sterken, M. G., et al. (2019). A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits. BMC Biology, 17: 24. doi:10.1186/s12915-019-0642-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6FD5-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D18F-F
Genre: Journal Article

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Snoek2019_Article_AMulti-parentRecombinantInbred.pdf (Publisher version), 8MB
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 Creators:
Snoek, Basten L., Author
Volkers, Rita J. M., Author
Nijveen, Harm, Author
Petersen, Carola, Author
Dirksen, Philipp1, Author              
Sterken, Mark G., Author
Nakad, Rania, Author
Riksen, Joost A. G., Author
Rosenstiel, Philip, Author
Stastna, Jana J., Author
Braeckman, Bart P., Author
Harvey, Simon C., Author
Schulenburg, Hinrich1, Author              
Kammenga, Jan E., Author
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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 Abstract: The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and the genetic regulators of trait variation can be mapped on the genome using quantitative trait locus (QTL) analysis of recombinant inbred lines (RILs) derived from genetically and phenotypically divergent parents. Most RILs have been derived from crossing two parents from globally distant locations. However, the genetic diversity between local C. elegans populations can be as diverse as between global populations and could thus provide means of identifying genetic variation associated with complex traits relevant on a broader scale.

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Language(s): eng - English
 Dates: 2018-10-172019-02-262019-03-122019-12
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1186/s12915-019-0642-8
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Title: BMC Biology
Source Genre: Journal
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Publ. Info: Berlin ; Heidelberg : Springer
Pages: - Volume / Issue: 17 Sequence Number: 24 Start / End Page: - Identifier: ISSN: 1741-7007
CoNE: https://pure.mpg.de/cone/journals/resource/111071069889000