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  Hepatocyte Targeting of Antiviral Drugs Coupled to Galactosyl-Terminating Glycoproteins

Fiume, L., Busi, C., Mattioli, A., Balboni, P. G., Barbanti-Brodano, G., & Wieland, T. (1982). Hepatocyte Targeting of Antiviral Drugs Coupled to Galactosyl-Terminating Glycoproteins. In G. Gregoriadis (Ed.), Targeting of Drugs (pp. 1-17). New York - N.Y., London: Plenum Press.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6FD2-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6FD3-3
Genre: Book Chapter

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Gregoriadis_1982_TargetingOfDrugs_1.pdf (Any fulltext), 2MB
 
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 Creators:
Fiume, L., Author
Busi, C., Author
Mattioli, A., Author
Balboni, P. G., Author
Barbanti-Brodano, G., Author
Wieland, Theodor1, Author              
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Antiviral Drug; Cytosine Arabinoside; FEBS Letter; Lysosomotropic Agent; Adenine Arabinoside
 Abstract: This chapter deals with the possibility of specifically introducing inhibitors of DNA synthesis into hepatocytes by conjugation to galactosyl-terminating glycoproteins which are selectively taken up by parenchymal liver cells (Morell et al., 1968; Ashwell and Morell, 1974; Gregoriadis, 1975). This line of research, which was developed as an approach to the treatment of chronic hepatitis B, started from the finding (Derenzini et al., 1973) that β-amanitin after coupling to albumin changed its original target Ed selectively penetrated into cells of the macrophage system which are very active in internalising albumin.

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Language(s): eng - English
 Dates: 1982
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-1-4684-4241-0_1
 Degree: -

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Title: Targeting of Drugs
  Alternative Title : [proceedings ...]
  Alternative Title : NATO advanced study institutes series; Series A, Band 47
Source Genre: Book
 Creator(s):
Gregoriadis, Gregory, Editor
Affiliations:
-
Publ. Info: New York - N.Y., London : Plenum Press
Pages: 430 Volume / Issue: - Sequence Number: - Start / End Page: 1 - 17 Identifier: ISBN: 82003822
ISBN: 0-306-41001-X