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  Gene expression networks across multiple tissues are associated with rates of molecular evolution in wild house mice

Mack, K. L., Phifer-Rixey, M., Harr, B., & Nachman, M. W. (2019). Gene expression networks across multiple tissues are associated with rates of molecular evolution in wild house mice. Genes, 10(3): 225. doi:10.3390/genes10030225.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6FFE-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6FFF-3
Genre: Journal Article

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genes-10-00225.pdf (Publisher version), 2MB
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 Creators:
Mack, Katya L., Author
Phifer-Rixey, Megan, Author
Harr, Bettina1, Author              
Nachman, Michael W., Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: co-expression; gene regulation; house mice
 Abstract: Interactions between genes can influence how selection acts on sequence variation. In gene regulatory networks, genes that affect the expression of many other genes may be under stronger evolutionary constraint than genes whose expression affects fewer partners. While this has been studied for individual tissue types, we know less about the effects of regulatory networks on gene evolution across different tissue types. We use RNA-sequencing and genomic data collected from Mus musculus domesticus to construct and compare gene co-expression networks for 10 tissue types. We identify tissue-specific expression and local regulatory variation, and we associate these components of gene expression variation with sequence polymorphism and divergence. We found that genes with higher connectivity across tissues and genes associated with a greater number of cross-tissue modules showed significantly lower genetic diversity and lower rates of protein evolution. Consistent with this pattern, ldquo;hubrdquo; genes across multiple tissues also showed evidence of greater evolutionary constraint. Using allele-specific expression, we found that genes with cis-regulatory variation had lower average connectivity and higher levels of tissue specificity. Taken together, these results are consistent with strong purifying selection acting on genes with high connectivity within and across tissues.

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Language(s): eng - English
 Dates: 2019-03-102018-01-292019-03-112019-03-182019
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.3390/genes10030225
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Title: Genes
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI AG
Pages: 13 Volume / Issue: 10 (3) Sequence Number: 225 Start / End Page: - Identifier: ISSN: 2073-4425