English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Origination and evolution of orphan genes and de novo genes in the genome of Caenorhabditis elegans

Zhang, W., Gao, Y., Long, M., & Shen, B. (2019). Origination and evolution of orphan genes and de novo genes in the genome of Caenorhabditis elegans. Science China Life Sciences, 62(4), 579-593. doi:10.1007/s11427-019-9482-0.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7002-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7003-B
Genre: Journal Article

Files

show Files
hide Files
:
Zhang2019_Article_OriginationAndEvolutionOfOrpha.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
Zhang2019_Article_OriginationAndEvolutionOfOrpha.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Evolutionary Biology, Plön; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Zhang, Wenyu1, Author              
Gao, Yuanxiao2, Author              
Long, Manyuan, Author
Shen, Bairong, Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

Content

show
hide
Free keywords: Caenorhabditis elegans, orphan genes, de novo genes
 Abstract: Orphan genes that lack detectable homologues in other lineages could contribute to a variety of biological functions. However, their origination and function mechanisms remain largely unknown. Herein, through a comprehensive and systematic computational pipeline, we identified 893 orphan genes in the lineage of C. elegans, of which only a low fraction (0.9%) were derived from transposon elements. Six new protein-coding genes that de novo originated from non-coding DNA sequences in the genome of C. elegans were also identified. The authenticity and functionality of these orphan genes and de novo genes are supported by three lines of evidences, consisting of transcriptional data, and in silico proteomic data, and the fixation status data in wild populations. Orphan genes and de novo genes exhibited simple gene structures, such as, short in protein length, of fewer exons, and are frequently X-linked. RNA-seq data analysis showed these orphan genes are enriched with expression in embryo development and gonad, and their potential function in early development was further supported by gene ontology enrichment analysis results. Meanwhile, de novo genes were found to be with significant expression in gonad, and functional enrichment analysis of the co-expression genes of these de novo genes suggested they may be functionally involved in signaling transduction pathway and metabolism process. Our results presented the first systematic evidence on the evolution of orphan genes and de novo origin of genes in nematodes and their impacts on the functional and phenotypic evolution, and thus could shed new light on our appreciation of the importance of these new genes.

Details

show
hide
Language(s): eng - English
 Dates: 2019-01-112019-01-222019-03-212019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s11427-019-9482-0
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science China Life Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Science China Press and Springer Verlag
Pages: - Volume / Issue: 62 (4) Sequence Number: - Start / End Page: 579 - 593 Identifier: ISSN: 1674-7305
Other: 1869-1889
CoNE: https://pure.mpg.de/cone/journals/resource/1674-7305