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  The toxic peptides from Amanita mushrooms

Wieland, T. (1983). The toxic peptides from Amanita mushrooms. International journal of peptide and protein research, 22(3), 257-276. doi:10.1111/j.1399-3011.1983.tb02093.x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7207-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7208-4
Genre: Journal Article

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IntJPeptProtRes_22_1983_257.pdf (Any fulltext), 2MB
 
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 Creators:
Wieland, Theodor1, Author              
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1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: amatoxins; cyclic peptides; peptide thioethers; phallotoxins; tryptathionine; virotoxins
 Abstract: The results of 50 years of effort in the chemistry of Amanita toxins are reviewed. The phallotoxins, fast acting components, but not responsible for fatal intoxications after ingestion, are bicyclic heptapeptides. They combine with F-actin, stabilizing this protein against several destabilizing influences. The virotoxins likewise fast acting are monocyclic heptapeptides. The amatoxins which are the real toxins lead to death within several days by inhibiting the enzymatic synthesis of m-RNA. They are bicyclic octapeptides. The structures of all of these compounds are described, as well as conformations, chemical reactions and modification, syntheses and correlations between structures and biological activities.

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Language(s): eng - English
 Dates: 1982-12-131983-01-151983-09
 Publication Status: Published in print
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: International journal of peptide and protein research
Source Genre: Journal
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Publ. Info: Denmark : Copenhagen, Munksgaard.
Pages: - Volume / Issue: 22 (3) Sequence Number: - Start / End Page: 257 - 276 Identifier: ISSN: 0367-8377