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  The right response at the right time: Exploring helminth immune modulation in sticklebacks by experimental co-infection

Piecyk, A., Ritter, M., & Kalbe, M. (2019). The right response at the right time: Exploring helminth immune modulation in sticklebacks by experimental co-infection. Molecular Ecology. doi:/10.1111/mec.15106.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-73FF-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7400-A
Genre: Journal Article

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Piecyk_et_al-2019-Molecular_Ecology.pdf (Any fulltext), 843KB
 
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 Creators:
Piecyk, Agnes1, 2, Author              
Ritter, Marc1, Author              
Kalbe, Martin1, Author              
Affiliations:
1Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
2IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              

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Free keywords: host-parasite interaction, helminth immune modulation, gene expression, Gasterosteus aculeatus, Schistocephalus solidus, Diplostomum pseudospathaceum
 Abstract: Abstract Parasites are one of the strongest selective agents in nature. They select for hosts that evolve counter-adaptive strategies to cope with infection. Helminth parasites are special because they can modulate their hosts? immune responses. This phenomenon is important in epidemiological contexts, where co-infections may be affected. How different types of hosts and helminths interact with each other is insufficiently investigated. We used the three-spined stickleback (Gasterosteus aculeatus) ? Schistocephalus solidus model to study mechanisms and temporal components of helminth immune modulation. Sticklebacks from two contrasting populations with either high resistance (HR) or low resistance (LR) against S. solidus, were individually exposed to S. solidus strains with characteristically high growth (HG) or low growth (LG) in G. aculeatus. We determined the susceptibility to another parasite, the eye fluke Diplostomum pseudospathaceum, and the expression of 23 key immune genes at three time points after S. solidus infection. D. pseudospathaceum infection rates and the gene expression responses depended on host and S. solidus type and changed over time. Whereas the effect of S. solidus type was not significant after three weeks, T regulatory responses and complement components were up-regulated at later time points if hosts were infected with HG S. solidus. HR hosts showed a well-orchestrated immune response, which was absent in LR hosts. Our results emphasize the role of regulatory T cells and the timing of specific immune responses during helminth infections. This study elucidates the importance to consider different co-evolutionary trajectories and ecologies when studying host-parasite interactions. This article is protected by copyright. All rights reserved.

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Language(s): eng - English
 Dates: 2019-04-162019-04
 Publication Status: Published in print
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 Identifiers: DOI: /10.1111/mec.15106
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Title: Molecular Ecology
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0962-1083
CoNE: https://pure.mpg.de/cone/journals/resource/954925580119