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  Flagella-like beating of a single microtubule

Vilfan, A., Subramani, S., Bodenschatz, E., Golestanian, R., & Guido, I. (2019). Flagella-like beating of a single microtubule. Nano Letters, 19(5), 3359-3363. doi:10.1021/acs.nanolett.9b01091.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-779D-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-92B9-7
Genre: Journal Article

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 Creators:
Vilfan, Andrej1, Author              
Subramani, Smrithika2, Author              
Bodenschatz, Eberhard2, Author              
Golestanian, Ramin1, Author              
Guido, Isabella2, Author              
Affiliations:
1Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2570692              
2Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Kinesin motors can induce a buckling instability in a microtubule with a fixed minus end. Here we show that by modifying the surface with a protein-repellent functionalization and using clusters of kinesin motors, the microtubule can exhibit persistent oscillatory motion resembling the beating of sperm flagella. The observed period is of the order of 1 min. From the experimental images we theoretically determine a distribution of motor forces that explains the observed shapes using a maximum likelihood approach. A good agreement is achieved with a small number of motor clusters acting simultaneously on a microtubule. The tangential forces exerted by a cluster are mostly in the range 0 - 8 pN towards the microtubule minus end, indicating the action of 1 or 2 kinesin motors. The lateral forces are distributed symmetrically and mainly below 10 pN, while the lateral velocity has a strong peak around zero. Unlike well-known models for flapping filaments, kinesins are found to have a strong “pinning” effect on the beating filaments. Our results suggest new strategies to utilize molecular motors in dynamic roles that depend sensitively on the stress built-up in the system.

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Language(s): eng - English
 Dates: 2019-04-182019
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acs.nanolett.9b01091
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Title: Nano Letters
Source Genre: Journal
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Pages: - Volume / Issue: 19 (5) Sequence Number: - Start / End Page: 3359 - 3363 Identifier: -