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  The Developmental Transcriptome for Lytechinus variegatus Exhibits Temporally Punctuated Gene Expression Changes

Hogan, J. D., Keenan, J. L., Luo, L., Hawkins, D. Y., Ibn-Salem, J., Lamba, A., et al. (2019). The Developmental Transcriptome for Lytechinus variegatus Exhibits Temporally Punctuated Gene Expression Changes. bioRxiv (Preprint Server), 2019: 572388. doi:10.1101/572388.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-79A9-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-79AA-6
Genre: Other

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 Creators:
Hogan, John D. , Author
Keenan, Jessica L., Author
Luo, Lingqi, Author
Hawkins, Dakota Y. , Author
Ibn-Salem, Jonas , Author
Lamba, Arjun, Author
Schatzberg, Daphne, Author
Piacentino, Michael L., Author
Zuch, Daniel T. , Author
Core, Amanda B. , Author
Blumberg, Carolyn , Author
Timmermann, Bernd1, Author              
Grau, José Horacio , Author
Speranza, Emily , Author
Andrade-Narravo, Miguel A. , Author
Irie, Naokie, Author
Poustka, Albert J., Author
Bradham, Cynthia A. , Author
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly valuable model organism for understanding developmental specification, morphogenesis, and evolution. As a non-chordate deuterostome, the sea urchin occupies an important evolutionary niche between protostomes and vertebrates. Lytechinus variegatus (Lv) is an Atlantic species that has been well studied, and which has provided important insights into signal transduction, patterning, and morphogenetic changes during embryonic and larval development. The Pacific species, Strongylocentrotus purpuratus (Sp), is another well-studied sea urchin, particularly for gene regulatory networks (GRNs) and cis-regulatory analyses. A well-annotated genome and transcriptome for Sp are available, but similar resources have not been developed for Lv. Here, we provide an analysis of the Lv transcriptome at 11 timepoints during embryonic and larval development. The data indicate that the gene regulatory networks that underlie specification are well-conserved among sea urchin species. We show that the major transitions in variation of embryonic transcription divide the developmental time series into four distinct, temporally sequential phases. Our work shows that sea urchin development occurs via sequential intervals of relatively stable gene expression states that are punctuated by abrupt transitions.

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Language(s): eng - English
 Dates: 2019-03-08
 Publication Status: Published online
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 Identifiers: DOI: 10.1101/572388
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Title: bioRxiv (Preprint Server)
Source Genre: Journal
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Publ. Info: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory
Pages: - Volume / Issue: 2019 Sequence Number: 572388 Start / End Page: - Identifier: -