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  The impact of hyperosmolality on activation and differentiation of B lymphoid cells

Cvetkovic, L., Perisic, S., Titze, J., Jäck, H.-M., & Schuh, W. (2019). The impact of hyperosmolality on activation and differentiation of B lymphoid cells. Frontiers in immunology, e-pup(828): e-pup, pp. 1-10. doi:10.3389/fimmu.2019.00828.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7DD9-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7DDA-C
Genre: Journal Article

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FrontImmunology_10_2019_828.pdf (Any fulltext), 3MB
 
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 Creators:
Cvetkovic, Ljiljana, Author
Perisic, Stojan1, Author              
Titze, Jens, Author
Jäck, Hans-Martin, Author
Schuh, Wolfgang, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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 Abstract: B lymphocytes, as a central part of adaptive immune responses, have the ability to fight against an almost unlimited numbers of pathogens. Impairment of B cell development, activation and differentiation to antibody secreting plasma cells can lead to malignancy, allergy, autoimmunity and immunodeficiency. However, the impact of environmental factors, such as hyperosmolality or osmotic stress caused by varying salt concentrations in different lymphoid organs, on these processes is not well-understood. Here, we report that B cells respond to osmotic stress in a biphasic manner. Initially, increased osmolality boosted B cell activation and differentiation as shown by an untimely downregulation of Pax5 as well as upregulation of CD138. However, in the second phase, we observed an increase in cell death and impaired plasmablast differentiation. Osmotic stress resulted in impaired class switch to IgG1, inhibition of phosphorylation of p38 mitogen-activated kinase and a delayed NFAT5 response. Overall, these findings demonstrate the importance of microenvironmental hyperosmolality and osmotic stress caused by NaCl for B cell activation and differentiation.

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Language(s): eng - English
 Dates: 2018-11-292019-03-282019-04-18
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fimmu.2019.00828
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Title: Frontiers in immunology
  Abbreviation : Front immunol
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: e-pup (828) Sequence Number: e-pup Start / End Page: 1 - 10 Identifier: ISSN: 1664-3224
CoNE: https://pure.mpg.de/cone/journals/resource/1664-3224