Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Surface immobilized E-cadherin mimetic peptide regulates the adhesion and clustering of epithelial cells

Li, J., Di Russo, J., Hua, X., Chu, Z., Spatz, J. P., & Wei, Q. (2019). Surface immobilized E-cadherin mimetic peptide regulates the adhesion and clustering of epithelial cells. Advanced Healthcare Materials, 8(8): 1801384, pp. 1-12. doi:10.1002/adhm.201801384.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-7E57-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-FFFD-0
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
AdvHealthcareMater_8_2019_1801384.pdf (beliebiger Volltext), 5MB
 
Datei-Permalink:
-
Name:
AdvHealthcareMater_8_2019_1801384.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-
:
AdvHealthcareMater_8_2019_1801384_Suppl.pdf (Ergänzendes Material), 4MB
 
Datei-Permalink:
-
Name:
AdvHealthcareMater_8_2019_1801384_Suppl.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
externe Referenz:
https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.201801384 (beliebiger Volltext)
Beschreibung:
-
OA-Status:
externe Referenz:
https://doi.org/10.1002/adhm.201801384 (beliebiger Volltext)
Beschreibung:
-
OA-Status:
externe Referenz:
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.201801384&file=adhm201801384-sup-0001-S1.pdf (Ergänzendes Material)
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Li, Jie1, Autor           
Di Russo, Jacopo1, Autor           
Hua, Ximeng1, Autor           
Chu, Zhiqin, Autor
Spatz, Joachim P.1, 2, Autor           
Wei, Qiang1, 2, Autor           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: E-cadherin mimetic peptides; cell adhesion; cell clusters; epithelial cells; surface immobilization
 Zusammenfassung: Cadherin mimetic peptides are widely used in synthetic biomaterials to mimic cell-cell adhesion in cell microniches. This mimicry regulates various cell behaviors. Although the interaction between immobilized cadherin and cells is investigated in numerous studies, the exact manner of functioning of cadherin mimetic peptides is yet to be fully understood. Cadherin mimetic peptides mimic only the critical amino acid sequence of cadherin and are not equal to these proteins in function. Compared to the cadherin proteins, mimetic peptides are more stable, easier to fabricate, and exhibit a precise chemical composition. In this study the E-cadherin mimetic peptide His-Ala-Val (HAV) on material surfaces is immobilized and epithelial cell adhesion and clustering are studied. The results suggest that immobilized HAV peptides specifically interact with E-cadherin on the cell membrane, resulting in an increased expression of E-cadherin and its downstream signaling protein β-catenin. This interaction relocates E-cadherin-based adhesion from the cell-cell interface to the cell-materials interface, which promotes cell adhesion via mechanosensing and initiates a transition in the cell cluster from a solid-like to a fluid-like state. The study presents an overview of the interactions between E-cadherin mimetic peptide and epithelial cells to aid in the design of novel biomaterials.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019-03-032018-10-292019-03-25
 Publikationsstatus: Online veröffentlicht
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/adhm.201801384
URI: https://www.ncbi.nlm.nih.gov/pubmed/30908895
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Advanced Healthcare Materials
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Wiley-VCH
Seiten: - Band / Heft: 8 (8) Artikelnummer: 1801384 Start- / Endseite: 1 - 12 Identifikator: ISSN: 2192-2640
CoNE: https://pure.mpg.de/cone/journals/resource/2192-2640