English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  CEST MR-Fingerprinting: practical considerations and insights for acquisition schedule design and improved reconstruction

Perlman, O., Herz, K., Zaiss, M., Cohen, O., Rosen, M., & Farrar, C. (submitted). CEST MR-Fingerprinting: practical considerations and insights for acquisition schedule design and improved reconstruction.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7EB7-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EB8-1
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://arxiv.org/abs/1904.09732 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Perlman, O, Author
Herz, K1, 2, Author              
Zaiss, M1, 2, Author              
Cohen, O, Author
Rosen, MS, Author
Farrar, CT, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Purpose: To understand the influence of various acquisition parameters on the ability of CEST MR-Fingerprinting (MRF) to discriminate different chemical exchange parameters and to provide tools for optimal acquisition schedule design and parameter map reconstruction. Methods: Numerical simulations were conducted using a parallel-computing implementation of the Bloch-McConnell equations, examining the effect of TR, TE, flip-angle, water T1 and T2, saturation-pulse duration, power, and frequency on the discrimination ability of CEST-MRF. A modified Euclidean-distance matching metric was evaluated and compared to traditional dot-product matching. L-Arginine phantoms of various concentrations and pH were scanned at 4.7T and the results compared to numerical findings. Results: Simulations for dot-product matching demonstrated that the optimal flip-angle and saturation times are 30∘ and 1100 ms, respectively. The optimal maximal saturation power was 3.4 μT for concentrated solutes with a slow exchange-rate, and 5.2 μT for dilute solutes with medium-to-fast exchange-rates. Using the Euclidean-distance matching metric, much lower maximum saturation powers were required (1.6 and 2.4 μT, respectively), with a slightly longer saturation time (1500 ms) and 90∘ flip-angle. For both matching metrics, the discrimination ability increased with the repetition time. The experimental results were in agreement with simulations, demonstrating that more than a 50% reduction in scan-time can be achieved by Euclidean-distance-based matching. Conclusion: Optimization of the CEST-MRF acquisition schedule is critical for obtaining the best exchange parameter accuracy. The use of Euclidean-distance-based matching of signal trajectories simultaneously improved the discrimination ability and reduced the scan time and maximal saturation power required.

Details

show
hide
Language(s):
 Dates: 2019-04
 Publication Status: Submitted
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: -
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -