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  Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status

Berer, K., Martinez, I., Walker, A., Kunkel, B., Schmitt-Kopplin, P., Walter, J., et al. (2018). Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status. Scientific Reports, 8: 10431. doi:10.1038/s41598-018-28839-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7FE2-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7FE9-9
Genre: Journal Article

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 Creators:
Berer, Kerstin1, Author              
Martinez, Ines2, Author
Walker, Alesia2, Author
Kunkel, Birgit1, Author              
Schmitt-Kopplin, Philippe2, Author
Walter, Jens2, Author
Krishnamoorthy, Gurumoorthy2, Author              
Affiliations:
1Emeritus Group: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2external, ou_persistent22              

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Free keywords: MULTIPLE-SCLEROSIS PATIENTS; MICROBIAL METABOLITES; FATTY-ACIDS; TH2 CELLS; T-CELLS; ENCEPHALOMYELITIS; CYTOKINES; CELLULOSE; PROTECT; MICEScience & Technology - Other Topics;
 Abstract: The autoimmune neurological disease, Multiple Sclerosis (MS), have increased at alarming rates in the Western society over the last few decades. While there are numerous efforts to develop novel treatment approaches, there is an unmet need to identify preventive strategies. We explored whether central nervous system (CNS) autoimmunity can be prevented through dietary manipulation using a spontaneous autoimmune encephalomyelitis mouse model. We report that the nutritional supplementation of non-fermentable fiber, common components of a vegetarian diet, in early adult life, prevents autoimmune disease. Dietary non-fermentable fiber alters the composition of the gut microbiota and metabolic profile with an increase in the abundance of long-chain fatty acids. Immune assays revealed that cecal extracts and a long chain fatty acid but not cecal lysates promoted autoimmune suppressive T(H)2 immune responses, demonstrating that non-fermentable fiber-induced metabolic changes account for the beneficial effects. Overall, these findings identify a non-invasive dietary strategy to prevent CNS autoimmunity and warrants a focus on nutritional approaches in human MS.

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Language(s): eng - English
 Dates: 2018-07-11
 Publication Status: Published online
 Pages: 12
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 Table of Contents: -
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Project name : SFB TR-128 (Project A1)
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Funding organization : German research foundation (DFG)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 10431 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322