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  Cross-reactivity as a mechanism linking infections to stroke

Lucchese, G., Flöel, A., & Stahl, B. (2019). Cross-reactivity as a mechanism linking infections to stroke. Frontiers in Neurology, 10: 469. doi:10.3389/fneur.2019.00469.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-8659-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-54D3-D
Genre: Journal Article

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Lucchese_Flöel_2019.pdf (Publisher version), 323KB
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 Creators:
Lucchese, Guglielmo1, 2, Author
Flöel, Agnes1, Author
Stahl, Benjamin1, 3, 4, 5, Author              
Affiliations:
1Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
2Goldsmiths, University of London, United Kingdom, ou_persistent22              
3Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Psychologische Hochschule Berlin, Germany, ou_persistent22              

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Free keywords: Stroke; Infections; Cross-reaction; Peptides; Cross-reactivity
 Abstract: The relevance of infections as risk factor for cerebrovascular disease is being increasingly recognized. Nonetheless, the pathogenic link between the two entities remains poorly understood. Consistent with recent advances in medicine, the present work addresses the hypothesis that infection-induced immune responses may affect human proteins associated with stroke. Applying established procedures in bioinformatics, the pathogen antigens and the human proteins were searched for common sequences using pentapeptides as probes. The data reported demonstrate massive peptide sharing between infectious pathogens—such as Chlamydia pneumoniae, Streptococcus pneumoniae, Tannerella forsythia, Haemophilus influenzae, Influenza A virus and Cytomegalovirus—and human proteins related to risk of ischemic and hemorrhagic stroke. Moreover, these data confirm that the shared peptides are also evident in a number of epitopes experimentally proven immunopositive in the human host. The present data suggest cross-reactivity as a potential mechanistic link between infections and stroke.

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Language(s): eng - English
 Dates: 2019-01-272019-04-172019-05-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fneur.2019.00469
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Project name : -
Grant ID : 393148499
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Funding organization : German Research Foundation (DFG)
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Funding program : Open Access Publication Fund
Funding organization : University of Greifswald
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Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Frontiers in Neurology
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 469 Start / End Page: - Identifier: ISSN: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295