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  BRACHYURY directs histone acetylation to target loci during mesoderm development

Beisaw, A., Tsaytler, P., Koch, F., Schmitz, S. U., Melissari, M.-T., Senf, A. D., et al. (2018). BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Reports, 19(1), 118-134. doi:10.15252/embr.201744201.

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© 2017 The Authors

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 Urheber:
Beisaw, Arica , Autor
Tsaytler, Pavel , Autor
Koch, Frederic , Autor
Schmitz, Sandra U. , Autor
Melissari, Maria-Theodora , Autor
Senf, Anna D. , Autor
Wittler, Lars1, Autor           
Pennimpede, Tracie , Autor
Macura, Karol1, Autor           
Herrmann, Bernhard G.1, Autor           
Grote, Phillip , Autor
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Schlagwörter: Brachyury ; Lmo2 ; H3K27 acetylation; T‐box factors; autoregulation
 Zusammenfassung: T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (TY88A) results in decreased histone 3 lysine 27 acetylation (H3K27ac) at T target sites, including the T locus, suggesting that T autoregulates the maintenance of its expression and functions by recruiting permissive chromatin modifications to putative enhancers during mesoderm specification. Our data indicate that T mediates H3K27ac recruitment through a physical interaction with p300. In addition, we determine that T plays a prominent role in the specification of hematopoietic and endothelial cell types. Hematopoietic and endothelial gene expression programs are disrupted in TY88A mutant embryos, leading to a defect in the differentiation of hematopoietic progenitors. We show that this role of T is mediated, at least in part, through activation of a distal Lmo2 enhancer.

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Sprache(n): eng - English
 Datum: 2017-10-252017-11-152018-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.15252/embr.201744201
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Titel: EMBO Reports
  Andere : EMBO Rep.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford, UK : Published for EMBO by Oxford University Press
Seiten: 17 Band / Heft: 19 (1) Artikelnummer: - Start- / Endseite: 118 - 134 Identifikator: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661