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  The Role of the Locus Coeruleus in Cellular and Systems Memory Consolidation

Eschenko, O. (2018). The Role of the Locus Coeruleus in Cellular and Systems Memory Consolidation. In D. Manahan-Vaughan (Ed.), Handbook of in vivo neural plasticity techniques: a systems neuroscience approach to the neural basis of memory and cognition (pp. 327-347). London, UK: Academic Press.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-89D0-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-89DF-8
Genre: Book Chapter

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 Creators:
Eschenko, O1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Synaptic plasticity, neuronal replay, and cross-regional communication are considered key physiological processes underlying memory consolidation. Both cellular and systems-level consolidation hypotheses are supported by extensive empirical evidence. However, presently, little is known about the temporal relations between local synaptic modifications and activity dynamics within extended neuronal networks supporting memory. The diffuse ascending neuromodulatory systems, with the locus coeruleus (LC) noradrenergic system being one of them, appear to be ideal candidates for bridging the cellular and systems mechanisms of memory consolidation. According to a canonical view, noradrenaline release from the terminal fields of LC neurons creates a window of heightened synaptic plasticity within a recently activated neuronal network. Importantly, this neuromodulatory input is critical at times of actual learning experience but also functions “off-line,” when experience-activated neuronal ensembles replay and protein-dependent synaptic modifications occur. Tracking the connectivity strength within learning-related large-scale networks combined with monitoring neuromodulatory activity and behavioral assessment of memory appear irreplaceable methodology for examining interactions between cellular and systems mechanisms of memory consolidation, which are both dependent on neuromodulation.

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 Dates: 2018
 Publication Status: Published in print
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Title: Handbook of in vivo neural plasticity techniques: a systems neuroscience approach to the neural basis of memory and cognition
Source Genre: Book
 Creator(s):
Manahan-Vaughan, D, Editor
Affiliations:
-
Publ. Info: London, UK : Academic Press
Pages: 540 Volume / Issue: - Sequence Number: 18 Start / End Page: 327 - 347 Identifier: ISBN: 978-0-12-812028-6

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Title: Handbook of Behavioral Neuroscience
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Pages: - Volume / Issue: 28 Sequence Number: - Start / End Page: - Identifier: -