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  Spatial gradients of healthy aging: A study of myelin-sensitive maps

Karolis, V. R., Callaghan, M. F., Tseng, C.-E.-J., Hope, T., Weiskopf, N., Rees, G., et al. (2019). Spatial gradients of healthy aging: A study of myelin-sensitive maps. Neurobiology of Aging, 79, 83-92. doi:10.1016/j.neurobiolaging.2019.03.002.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-89D2-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-DCEA-B
Genre: Journal Article

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 Creators:
Karolis, Vyacheslav R.1, 2, Author
Callaghan, Martina F.3, Author
Tseng, Chieh-En Jane2, 4, Author
Hope, Thomas3, Author
Weiskopf, Nikolaus3, 5, Author           
Rees, Geraint6, Author
Cappelletti, Marinella6, 7, Author
Affiliations:
1FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
2Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Radiology, Harvard Medical School, Boston, MA, USA, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
6Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
7Department of Psychology, Goldsmiths, University of London, United Kingdom, ou_persistent22              

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Free keywords: Aging; Gradient; Maturation; Myelin; Magnetization transfer
 Abstract: Protracted development of a brain network may entail greater susceptibility to aging decline, supported by evidence of an earlier onset of age-related changes in late-maturing anterior areas, that is, an anterior-to-posterior gradient of brain aging. Here we analyzed the spatiotemporal features of age-related differences in myelin content across the human brain indexed by magnetization transfer (MT) concentration in a cross-sectional cohort of healthy adults. We described age-related spatial gradients in MT, which may reflect the reversal of patterns observed in development. We confirmed an anterior-to-posterior gradient of age-related MT decrease and also showed a lateral-to-ventral gradient inversely mirroring the sequence of connectivity development and myelination. MT concentration in the lateral white matter regions continued to increase up to the age of 45 years and decreased moderately following a peak. In contrast, ventral white matter regions reflected life-long stable MT concentration levels, followed by a rapid decrease at a later age. We discussed our findings in relation with existing theories of brain aging, including the lack of support for the proposal that areas which mature later decline at an accelerated rate.

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Language(s): eng - English
 Dates: 2019-02-062017-09-082019-03-052019-03-122019-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2019.03.002
PMID: 31029019
Other: Epub 2019
 Degree: -

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Project name : -
Grant ID : 502008.K518/SLB
Funding program : Royal Society Dorothy Hodgkin Fellowship
Funding organization : The Royal Society
Project name : -
Grant ID : -
Funding program : Royal Society Research Grant
Funding organization : The Royal Society
Project name : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) /
Grant ID : 616905
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : 097720/Z/11/Z
Funding program : Wellcome Trust Principal Research Fellowship
Funding organization : Wellcome Trust
Project name : -
Grant ID : MR/M023672/1
Funding program : Medical Research Council Project Grant
Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : UK TSA 2014/02 (TH)
Funding program : Stroke Association Project Grant
Funding organization : Stroke Association
Project name : -
Grant ID : 091593/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust

Source 1

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 79 Sequence Number: - Start / End Page: 83 - 92 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902