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  Spatial gradients of healthy aging: A study of myelin-sensitive maps

Karolis, V. R., Callaghan, M. F., Tseng, C.-E.-J., Hope, T., Weiskopf, N., Rees, G., et al. (2019). Spatial gradients of healthy aging: A study of myelin-sensitive maps. Neurobiology of Aging, 79, 83-92. doi:10.1016/j.neurobiolaging.2019.03.002.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-89D2-5 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0006-DCEA-B
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Callaghan_Spatial gradients of healthy aging. A study of myelin-sensitive maps_AAM.pdf (Postprint), 9MB
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https://doi.org/10.1016/j.neurobiolaging.2019.03.002 (Verlagsversion)
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 Urheber:
Karolis, Vyacheslav R.1, 2, Autor
Callaghan, Martina F.3, Autor
Tseng, Chieh-En Jane2, 4, Autor
Hope, Thomas3, Autor
Weiskopf, Nikolaus3, 5, Autor           
Rees, Geraint6, Autor
Cappelletti, Marinella6, 7, Autor
Affiliations:
1FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
2Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Radiology, Harvard Medical School, Boston, MA, USA, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
6Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
7Department of Psychology, Goldsmiths, University of London, United Kingdom, ou_persistent22              

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Schlagwörter: Aging; Gradient; Maturation; Myelin; Magnetization transfer
 Zusammenfassung: Protracted development of a brain network may entail greater susceptibility to aging decline, supported by evidence of an earlier onset of age-related changes in late-maturing anterior areas, that is, an anterior-to-posterior gradient of brain aging. Here we analyzed the spatiotemporal features of age-related differences in myelin content across the human brain indexed by magnetization transfer (MT) concentration in a cross-sectional cohort of healthy adults. We described age-related spatial gradients in MT, which may reflect the reversal of patterns observed in development. We confirmed an anterior-to-posterior gradient of age-related MT decrease and also showed a lateral-to-ventral gradient inversely mirroring the sequence of connectivity development and myelination. MT concentration in the lateral white matter regions continued to increase up to the age of 45 years and decreased moderately following a peak. In contrast, ventral white matter regions reflected life-long stable MT concentration levels, followed by a rapid decrease at a later age. We discussed our findings in relation with existing theories of brain aging, including the lack of support for the proposal that areas which mature later decline at an accelerated rate.

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Sprache(n): eng - English
 Datum: 2019-02-062017-09-082019-03-052019-03-122019-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neurobiolaging.2019.03.002
PMID: 31029019
Anderer: Epub 2019
 Art des Abschluß: -

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Projektname : -
Grant ID : 502008.K518/SLB
Förderprogramm : Royal Society Dorothy Hodgkin Fellowship
Förderorganisation : The Royal Society
Projektname : -
Grant ID : -
Förderprogramm : Royal Society Research Grant
Förderorganisation : The Royal Society
Projektname : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) /
Grant ID : 616905
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 097720/Z/11/Z
Förderprogramm : Wellcome Trust Principal Research Fellowship
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : MR/M023672/1
Förderprogramm : Medical Research Council Project Grant
Förderorganisation : Medical Research Council (MRC)
Projektname : -
Grant ID : UK TSA 2014/02 (TH)
Förderprogramm : Stroke Association Project Grant
Förderorganisation : Stroke Association
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust

Quelle 1

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Titel: Neurobiology of Aging
  Andere : Neurobiol. Aging
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY [etc.] : Elsevier
Seiten: - Band / Heft: 79 Artikelnummer: - Start- / Endseite: 83 - 92 Identifikator: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902