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  Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk

Schad, D. J., Garbusow, M., Friedel, E., Sommer, C., Sebold, M., Hägele, C., et al. (2019). Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk. European Archives of Psychiatry and Clinical Neuroscience, 269(3), 295-308. doi:10.1007/s00406-017-0860-4.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-8C27-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B31A-6
Genre: Journal Article

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 Creators:
Schad, Daniel J.1, 2, Author
Garbusow, Maria1, 3, Author
Friedel, Eva1, 4, Author
Sommer, Christian5, Author
Sebold, Miriam1, 3, Author
Hägele, Claudia1, Author
Bernhardt, Nadine6, Author
Nebe, Stephan6, Author
Kuitunen-Paul, Sören7, Author
Liu, Shuyan1, Author
Eichmann, Uta8, Author
Beck, Anne1, Author
Wittchen, Hans-Ulrich7, 9, Author
Walter, Henrik1, Author
Sterzer, Philipp1, Author
Zimmermann, Ulrich S.5, Author
Smolka, Michael N.6, Author
Schlagenhauf, Florian1, 10, Author              
Huys, Quentin J. M.11, 12, Author
Heinz, Andreas1, Author
Rapp, Michael A.2, Author more..
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
3Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Berlin Institute of Health (BIH), Germany, ou_persistent22              
5Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              
6Neuroimaging Center, TU Dresden, Germany, ou_persistent22              
7Institute of Clinical Psychology and Psychotherapy, TU Dresden, Germany, ou_persistent22              
8Department of Psychiatry, Psychotherapy, and Psychosomatics, Vivantes Hospitals, Berlin, Germany, ou_persistent22              
9Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany, ou_persistent22              
10Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_1753350              
11Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
12Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Zurich, Switzerland, ou_persistent22              

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Free keywords: Alcohol dependence; Human neuroimaging; Nucleus accumbens; Pavlovian-instrumental transfer; Relapse
 Abstract: The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = − 3.86, p < .001), but not in healthy controls (t = − 0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t(30) = 2.06, p < .05). Interestingly, both the effects were only present in subsequent abstainers, but not relapsers and in those with mild but not severe dependence. Our data show that alcohol-related cues can acquire inhibitory behavioral features typical of aversive stimuli despite being accompanied by a stronger NAcc activation, suggesting salience attribution. The fact that these findings are restricted to abstinence and milder illness suggests that they may be potential resilience factors.

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Language(s): eng - English
 Dates: 2016-09-302017-12-022018-01-082019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00406-017-0860-4
PMID: 29313106
Other: Epub 2018
 Degree: -

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Project name : Lern- und Gewöhnungsprozesse als Prädiktoren für die Entwicklung und Aufrechterhaltung alkoholbezogener Störungen / FOR 1617
Grant ID : HE 2597/13-1 ; HE 2597/13-2 ; HE 2597/14-1 ; HE 2597/14-2 ; HE 2597/15-1 ; HE 2597/15-2 ; RA 1047/2-1 ; RA 1047/2-2 ; SCHA 1971/1-2 ; SCHA 1971/1-2 ; SCHL 1969/2-1 ; SCHL 1969/2-2 ; SM 80/7-1 ; SM 80/7-2 ; WI 709/10-1 ; WI 709/10-2 ; ZI 1119/3-1 ; ZI 1119/3-2
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Charite - University Medicine Berlin
Project name : -
Grant ID : -
Funding program : -
Funding organization : Berlin Instititute of Health (BIH)

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Title: European Archives of Psychiatry and Clinical Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer International
Pages: - Volume / Issue: 269 (3) Sequence Number: - Start / End Page: 295 - 308 Identifier: ISSN: 0940-1334
CoNE: https://pure.mpg.de/cone/journals/resource/954927622119