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  Iron, myelin, and the brain: Neuroimaging meets neurobiology

Möller, H. E., Bossoni, L., Connor, J. R., Crichton, R. R., Does, M. D., Ward, R. J., et al. (2019). Iron, myelin, and the brain: Neuroimaging meets neurobiology. Trends in Neurosciences, 42(6), 384-401. doi:10.1016/j.tins.2019.03.009.

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Möller, Harald E.1, Author              
Bossoni, Lucia2, Author
Connor, James R.3, Author
Crichton, Robert R.4, Author
Does, Mark D.5, Author
Ward, Roberta J.6, Author
Zecca, Luigi7, 8, Author
Zucca, Fabio A.7, Author
Ronen, Itamar2, Author
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, the Netherlands, ou_persistent22              
3Department of Neurosurgery, Penn State College of Medicine, Hershey, PA, USA, ou_persistent22              
4Université Catholique de Louvain, Belgium, ou_persistent22              
5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA, ou_persistent22              
6Centre of Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
7Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy, ou_persistent22              
8Department of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, NY, USA, ou_persistent22              


Free keywords: Aging and neurodegeneration; Iron biology; Magnetic resonance imaging; Magnetic susceptibility; Myelin; Water proton relaxation
 Abstract: Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.


Language(s): eng - English
 Dates: 2019-04-292019-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tins.2019.03.009
PMID: 31047721
Other: Epub 2019
 Degree: -



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Project name : -
Grant ID : 016.188.040
Funding program : Veni-Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
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Grant ID : -
Funding program : -
Funding organization : Italian Ministry of University and Research (MIUR)
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Grant ID : -
Funding program : -
Funding organization : National Research Council of Italy (CNR)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Grigioni Foundation for Parkinsons Disease
Project name : Flagship InterOmics Project
Grant ID : PB.P05
Funding program : -
Funding organization : Institute of Applied Mathematics and Information Technology (IMATI)

Source 1

Title: Trends in Neurosciences
  Other : Trends Neurosci.
Source Genre: Journal
Publ. Info: Oxford : Elsevier Current Trends
Pages: - Volume / Issue: 42 (6) Sequence Number: - Start / End Page: 384 - 401 Identifier: ISSN: 0166-2236
CoNE: https://pure.mpg.de/cone/journals/resource/954927741850