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  Unhealthy yet avoidable: How cognitive bias modification alters behavioral and brain responses to food cues in individuals with obesity

Mehl, N., Morys, F., Villringer, A., & Horstmann, A. (2019). Unhealthy yet avoidable: How cognitive bias modification alters behavioral and brain responses to food cues in individuals with obesity. Nutrients, 11(4): 874. doi:10.3390/nu11040874.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-8F74-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B31D-3
Genre: Journal Article

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 Creators:
Mehl, Nora1, 2, Author              
Morys, Filip1, 3, Author              
Villringer, Arno1, 3, 4, Author              
Horstmann, Annette1, 3, 4, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2MaxNetAging Research School, Max Planck Institute for Demographic Research, Rostock, Germany, ou_persistent22              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              

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Free keywords: Cognitive bias modification; Obesity; Approach–avoidance task; fMRI
 Abstract: Obesity is associated with automatically approaching problematic stimuli, such as unhealthy food. Cognitive bias modification (CBM) could beneficially impact problematic approach behavior. However, it is unclear which mechanisms are targeted by CBM in obesity. Candidate mechanisms include: (1) altering reward value of food stimuli; and (2) strengthening inhibitory abilities. Thirty-three obese adults completed either CBM or sham training during functional magnetic resonance imaging (fMRI) scanning. CBM consisted of implicit training to approach healthy and avoid unhealthy foods. At baseline, approach tendencies towards food were present in all participants. Avoiding vs. approaching food was associated with higher activity in the right angular gyrus (rAG). CBM resulted in a diminished approach bias towards unhealthy food, decreased activation in the rAG, and increased activation in the anterior cingulate cortex. Relatedly, functional connectivity between the rAG and right superior frontal gyrus increased. Analysis of brain connectivity during rest revealed training-related connectivity changes of the inferior frontal gyrus and bilateral middle frontal gyri. Taken together, CBM strengthens avoidance tendencies when faced with unhealthy foods and alters activity in brain regions underpinning behavioral inhibition

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Language(s): eng - English
 Dates: 2019-04-122019-03-102019-04-152019-04-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3390/nu11040874
PMID: 31003487
PII: E874
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Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)
Project name : -
Grant ID : 01E01001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Nutrients
  Other : Nutr. Cycl. Agroecosyst.
Source Genre: Journal
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Publ. Info: Dordrecht, The Netherlands : Kluwer
Pages: - Volume / Issue: 11 (4) Sequence Number: 874 Start / End Page: - Identifier: ISSN: 1385-1314
CoNE: https://pure.mpg.de/cone/journals/resource/954925621209