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  Alterations in BOLD Response and Metabolite Concentrations Support Decreased Glial Enzyme Activity in Major Depression: A Quantitative JPRESS and FMRI Study

Walter, M., Henning, A., Grimm, S., Schulte, R., Beck, J., Dydak, U., et al. (2008). Alterations in BOLD Response and Metabolite Concentrations Support Decreased Glial Enzyme Activity in Major Depression: A Quantitative JPRESS and FMRI Study. Poster presented at 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, Canada.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-9312-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9313-1
Genre: Poster

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 Creators:
Walter, M1, Author              
Henning, A1, Author              
Grimm, S, Author
Schulte, RF, Author
Beck, J, Author
Dydak, U, Author
Schnepf, B, Author
Böker, H, Author
Boesiger, P, Author
Northoff, G, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Metabolic and functional alterations inside the pgACC were assessed by simultaneous quantitative in-vivo 2D-JPRESS measurements of GABA, glutamate and glutamine levels, fMRI measurements during emotional stimulation and subjective evaluation of the emotional state in healthy volunteers and patients with major depressive disorder (MDD). An altered excitation/inhibition balance was found. Changed neurotransmitter concentrations specifically relate to reduced deactivation, and altered subjective evaluation of emotional intensities and anhedonia scores in the patient group. In addition, a decreased activity of glial enzymes that are mediating the Glu reuptake from the synaptic cleft as well as the transformation of glutamate into glutamine is hypothesized.

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 Dates: 2008-05
 Publication Status: Published in print
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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Place of Event: Toronto, Canada
Start-/End Date: 2008-05-03 - 2008-05-09

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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3552 Start / End Page: 571 Identifier: -