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  Ancient pathogen genomics as an emerging tool for infectious disease research

Spyrou, M. A., Bos, K. I., Herbig, A., & Krause, J. (2019). Ancient pathogen genomics as an emerging tool for infectious disease research. Nature Reviews Genetics, 20, 323-340. doi:10.1038/s41576-019-0119-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-93E6-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D704-6
Genre: Journal Article

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 Creators:
Spyrou, Maria A.1, Author              
Bos, Kirsten I.1, 2, Author              
Herbig, Alexander1, Author              
Krause, Johannes1, 3, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              
3MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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Free keywords: Infectious diseases, Metagenomics, Microbial genetics, Next-generation sequencing
 Abstract: Over the past decade, a genomics revolution, made possible through the development of high-throughput sequencing, has triggered considerable progress in the study of ancient DNA, enabling complete genomes of past organisms to be reconstructed. A newly established branch of this field, ancient pathogen genomics, affords an in-depth view of microbial evolution by providing a molecular fossil record for a number of human-associated pathogens. Recent accomplishments include the confident identification of causative agents from past pandemics, the discovery of microbial lineages that are now extinct, the extrapolation of past emergence events on a chronological scale and the characterization of long-term evolutionary history of microorganisms that remain relevant to public health today. In this Review, we discuss methodological advancements, persistent challenges and novel revelations gained through the study of ancient pathogen genomes.

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Language(s): eng - English
 Dates: 2019-04-052019
 Publication Status: Published in print
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41576-019-0119-1
Other: shh2222
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Title: Nature Reviews Genetics
Source Genre: Journal
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Publ. Info: London, UK : Nature Pub. Group
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 323 - 340 Identifier: ISSN: 1471-0056
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000939