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  Structural connectivity prior to whole-body sensorimotor skill learning associates with changes in resting state functional connectivity

Mizuguchi, N., Maudrich, T., Kenville, R., Carius, D., Maudrich, D., Villringer, A., et al. (2019). Structural connectivity prior to whole-body sensorimotor skill learning associates with changes in resting state functional connectivity. NeuroImage, 197, 191-199. doi:10.1016/j.neuroimage.2019.04.062.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-9601-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CBAC-7
Genre: Journal Article

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 Creators:
Mizuguchi, Nobuaki1, 2, 3, Author              
Maudrich, Tom1, 4, Author              
Kenville, Rouven1, 4, Author              
Carius, Daniel4, Author
Maudrich, Dennis1, Author              
Villringer, Arno1, 4, 5, Author              
Ragert, Patrick1, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Faculty of Science and Technology, Keio University, Tokyo, Japan, ou_persistent22              
3Japan Society for the Promotion of Sciences, Tokyo, Japan, ou_persistent22              
4Institute for General Kinesiology and Exercise Science, Faculty of Sport Science, University of Leipzig, Germany, ou_persistent22              
5Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Serial reaction time task; Resting state functional connectivity; Fixel-based analysis; Prefrontal cortex; Striatum; Motor skill
 Abstract: Changes in resting state functional connectivity are induced by sensorimotor training and assumed to be concomitant of motor learning, although a potential relationship between functional and structural connectivity associated with sensorimotor sequence learning remains elusive. To investigate whether initial structural connectivity relates to changes in functional connectivity, we evaluated resting state functional connectivity (rs-FC), white matter fibre density (FD), fibre-bundle cross-section (FC), and gray matter volume (GMV) in healthy human participants before and after two days of performing a complex whole-body serial reaction time task (CWB-SRTT). As CWB-SRTT was implicit, participants were not told about the presence of any sequence. Since the lateral prefrontal cortex (PFC) plays an important role in sequence learning, we hypothesized that structural connectivity within the PFC prior to learning is associated with changes in rs-FC involving the lateral PFC. Sequence specific improvements, as assessed by the time difference between the last random and the last sequence blocks, were observed for reaction times, suggesting that sensorimotor sequence memory was acquired. Rs-FC between the right lateral PFC and bilateral striatum increased significantly in the learning group, when compared to a control group who performed only random blocks. This indicated that rs-FC changes are related to sequence memory but not to exercise itself. In addition, changes in rs-FC between the right lateral PFC and the left striatum were correlated with sequence specific improvements in individual reaction times. Furthermore, changes in rs-FC between right lateral PFC and left striatum were positively correlated with FC in the right anterior corona radiata measured before the task. We did not find any structural changes or significant correlations in FD or GMV. These findings suggest that an early phase of sensorimotor sequence learning in complex whole-body movements is associated with an increase in rs-FC between prefrontal and subcortical regions. Furthermore, we provide novel evidence that CWB-SRTT-induced changes in rs-FC were correlated with FC within the PFC.

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Language(s): eng - English
 Dates: 2019-04-122018-11-292019-04-232019-04-252019-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.04.062
PMID: 31029869
Other: Epub ahead of print
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Project name : -
Grant ID : JP16J01324
Funding program : JSPS KAKENHI Grant
Funding organization : Japan Society for the Promotion of Science (JSPS)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck Society

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 197 Sequence Number: - Start / End Page: 191 - 199 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166