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  Control of retrograde signalling by protein import and cytosolic folding stress

Wu, G., Meyer, E. H., Richter, A. S., Schuster, M., Ling, Q., Schöttler, M. A., et al. (2019). Control of retrograde signalling by protein import and cytosolic folding stress. Nature Plants, 5(5), 525-538. doi:10.1038/s41477-019-0415-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-95F3-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4FCC-F
Genre: Journal Article

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 Creators:
Wu, G.1, Author              
Meyer, E. H.1, Author              
Richter, Andreas S.2, Author
Schuster, M.3, Author              
Ling, Qihua2, Author
Schöttler, M. A.4, Author              
Walther, D.5, Author              
Zoschke, R.3, Author              
Grimm, Bernhard2, Author
Jarvis, R. Paul2, Author
Bock, R.1, Author              
Affiliations:
1Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753326              
2external, ou_persistent22              
3Translational Regulation in Plants, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2324691              
4Photosynthesis Research, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753323              
5BioinformaticsCIG, Infrastructure Groups and Service Units, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753303              

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 Abstract: Communication between organelles and the nucleus is essential for fitness and survival. Retrograde signals are cues emitted from the organelles to regulate nuclear gene expression. GENOMES UNCOUPLED1 (GUN1), a protein of unknown function, has emerged as a central integrator, participating in multiple retrograde signalling pathways that collectively regulate the nuclear transcriptome. Here, we show that GUN1 regulates chloroplast protein import through interaction with the import-related chaperone cpHSC70-1. We demonstrated that overaccumulation of unimported precursor proteins (preproteins) in the cytosol causes a GUN phenotype in the wild-type background and enhances the GUN phenotype of the gun1 mutant. Furthermore, we identified the cytosolic HSP90 chaperone complex, induced by overaccumulated preproteins, as a central regulator of photosynthetic gene expression that determines the expression of the GUN phenotype. Taken together, our results suggest a model in which protein import capacity, folding stress and the cytosolic HSP90 complex control retrograde communication.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41477-019-0415-y
Other: Wu2019
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Title: Nature Plants
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 5 (5) Sequence Number: - Start / End Page: 525 - 538 Identifier: ISSN: 2055-0278
CoNE: https://pure.mpg.de/cone/journals/resource/2055-0278