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  Model-free generation of CEST contrast using principal components of Z-spectra at 3 T

Deshmane, A., Zaiss, M., Schuppert, M., Herz, K., & Scheffler, K. (2019). Model-free generation of CEST contrast using principal components of Z-spectra at 3 T. Poster presented at 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019), Montréal, QC, Canada.

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 Creators:
Deshmane, A1, 2, Author              
Zaiss, M1, 2, Author              
Schuppert, M1, 2, Author              
Herz, K1, 2, Author              
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Fitting of spectrally selective CEST contrasts requires models with limiting assumptions. Snapshot CEST allows us to densely sample the Z-spectrum with rapid volumetric imaging within a clinically feasible scan time. With over 60k spectra available per subject, statistically-driven analysis methods are now possible. Here we demonstrate that principle component analysis can be used for model-free analysis of spectral features. Projection of Z-spectra onto principle components from a group of healthy subjects provides several relevant contrasts which reveal anatomical detail and correlate with Gadolinium uptake signatures in a brain tumor patient.

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 Dates: 2019-05
 Publication Status: Published online
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Title: 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019)
Place of Event: Montréal, QC, Canada
Start-/End Date: 2019-05-11 - 2019-05-16

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Title: ISMRM 27th Annual Meeting & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 5003 Start / End Page: - Identifier: -