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  Denoising of Z-spectra for stable CEST MRI using principal component analysis

Breitling, J., Deshmane, A., Goerke, S., Herz, K., Ladd, M., Scheffler, K., et al. (2019). Denoising of Z-spectra for stable CEST MRI using principal component analysis. Poster presented at 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019), Montréal, QC, Canada.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-96DB-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C75D-5
Genre: Poster

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 Creators:
Breitling, J, Author
Deshmane, A1, 2, Author              
Goerke, S, Author
Herz, K1, 2, Author              
Ladd, M, Author
Scheffler, K1, 2, Author              
Bachert, P, Author
Zaiss, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Chemical exchange saturation transfer (CEST) MRI allows for the indirect detection of low-concentration biomolecules by their saturation transfer to the abundant water pool. However, reliable quantification of CEST effects remains challenging and requires a high image signal-to-noise ratio. In this study, we show that principle component analysis can provide a denoising capability which is comparable or better than 6-fold averaging. Principle component analysis allows identifying similarities across all noisy Z-spectra, and thus, extracting the relevant information. The resulting denoised Z-spectra provide a more stable basis for quantification of selective CEST effects, without requiring additional measurements.

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 Dates: 2019-05
 Publication Status: Published online
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Title: 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019)
Place of Event: Montréal, QC, Canada
Start-/End Date: 2019-05-11 - 2019-05-16

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Title: ISMRM 27th Annual Meeting & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0143 Start / End Page: - Identifier: -