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  Myelin and modeling: Bootstrapping cortical microcircuits

Turner, R. (2019). Myelin and modeling: Bootstrapping cortical microcircuits. Frontiers in Neural Circuits, 13: 34. doi:10.3389/fncir.2019.00034.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-983D-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E691-5
Genre: Journal Article

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 Creators:
Turner, Robert1, 2, 3, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              
3Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              

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Free keywords: Brain; Myelin; MRI; Cortical microcircuitry; Develoment; Modeling
 Abstract: Histological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally well-defined boundaries, which have consistent internal patterns of myelination. The process of myelination is largely driven by neural experience, in which the axonal passage of action potentials stimulates neighboring oligodendrocytes to perform their task. This bootstrapping process, such that the traffic of action potentials facilitates increased traffic, suggests the hypothesis that the specific pattern of myelination (myeloarchitecture) in each cortical area reveals the principal cortical microcircuits required for the function of that area. If this idea is correct, the observable sequential maturation of specific brain areas can provide evidence for models of the stages of cognitive development.

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Language(s): eng - English
 Dates: 2019-03-092019-04-252019-05-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fncir.2019.00034
PMID: 31133821
PMC: PMC6517540
Other: eCollection 2019
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Funding organization : Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig

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Title: Frontiers in Neural Circuits
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 34 Start / End Page: - Identifier: ISSN: 1662-5110
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5110