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  Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.

Raja, M. K., Preobraschenski, J., Del Olmo-Cabrera, S., Martinez-Turrillas, R., Jahn, R., Perez-Otano, I., et al. (2019). Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. eLife, 8: e40744. doi:10.7554/eLife.40744.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-9C51-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9C55-E
Genre: Journal Article

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 Creators:
Raja, M. K., Author
Preobraschenski, J.1, Author              
Del Olmo-Cabrera, S., Author
Martinez-Turrillas, R., Author
Jahn, R.1, Author              
Perez-Otano, I., Author
Wesseling, J. F., Author
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: RRP; STP; mouse; neuroscience; short-term plasticity; vesicle
 Abstract: Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic vesicle proteins such as vSNAREs and synaptotagmins, the primary function has not been resolved. Here, we report robust elevation in the probability of release of readily releasable vesicles with both high and low release probabilities at a variety of synapse types from knockout mice missing all four family members. Neither the number of readily releasable vesicles, nor the timing of recruitment to the readily releasable pool was affected. The results suggest that family members serve as negative regulators of neurotransmission, acting directly at the level of exocytosis to dampen connection strength selectively when presynaptic action potentials fire at low frequency. The widespread expression suggests that chemical synapses may play a frequency filtering role in biological computation that is more elemental than presently envisioned.

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Language(s): eng - English
 Dates: 2019-05-15
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.40744
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Title: eLife
Source Genre: Journal
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Pages: 23 Volume / Issue: 8 Sequence Number: e40744 Start / End Page: - Identifier: -