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  Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients

Paech, D., Dreher, C., Regnery, S., Meissner, J.-E., Goerke, S., Windschuh, J., et al. (2019). Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients. Poster presented at 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019), Montréal, QC, Canada.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-9D2C-C Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C717-3
Genre: Poster

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http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/2919.html (Abstract)
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 Creators:
Paech, D, Author
Dreher, C, Author
Regnery, S, Author
Meissner, J-E, Author
Goerke, S, Author
Windschuh, J, Author
Deike-Hofmann, K, Author
Bickelhaupt, S, Author
Radbruch, A, Author
Zaiss, M1, 2, Author           
Unterberg, A, Author
Wick, W, Author
Bendszus, M, Author
Bachert, P, Author
Ladd, M, Author
Schlemmer, H-P, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: In this work we show that relaxation-compensated amide proton transfer (APT) imaging at 7.0 T is associated with overall survival and progression-free survival in newly-diagnosed, previously untreated glioma patients. The current study showed that glioma patients with increased APT values were more likely to progress sooner and live shorter, respectively. This effect may be caused by strong alterations of amino acid concentrations and global upregulation of protein expression in more aggressive brain tumors. Therefore, APT CEST imaging may help to enhance the prognostic value of non-invasive MRI tools at the time of initial diagnosis and during follow-up.

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 Dates: 2019-05
 Publication Status: Published online
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Title: 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019)
Place of Event: Montréal, QC, Canada
Start-/End Date: 2019-05-11 - 2019-05-16

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Title: ISMRM 27th Annual Meeting & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2919 Start / End Page: - Identifier: -