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  Acute psychosocial stress increases serum BDNF levels: An antagonistic relation to cortisol but no group differences after mental training

Linz, R., Puhlmann, L. M., Apostolakou, F., Mantzou, E., Papassotiriou, I., Chrousos, G. P., et al. (2019). Acute psychosocial stress increases serum BDNF levels: An antagonistic relation to cortisol but no group differences after mental training. Neuropsychopharmacology, 44, 1797-1804. doi:10.1038/s41386-019-0391-y.

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Genre: Zeitschriftenartikel

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externe Referenz:
https://www.nature.com/articles/s41386-019-0391-y (Verlagsversion)
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 Urheber:
Linz, Roman1, 2, Autor           
Puhlmann, Lara M.1, 2, Autor           
Apostolakou, F.3, Autor
Mantzou, E.4, Autor
Papassotiriou, I. 3, Autor
Chrousos, G. P. 4, Autor
Engert, Veronika1, 2, Autor           
Singer, Tania2, 5, Autor           
Affiliations:
1Research Group Social Stress and Family Health, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025667              
2Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
3Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, Athens, Greece, ou_persistent22              
4First Department of Pediatrics, School of Medicine, “Aghia Sofia” General Children’s Hospital, Athens, Greece, ou_persistent22              
5Social Neuroscience Lab, Berlin, Germany, ou_persistent22              

Inhalt

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Schlagwörter: Adult; Affect; Attention; Brain-Derived Neurotrophic Factor; Cross-Sectional Studies; Empathy; Female; Humans; Hydrocortisone; Interoception; Male; Meditation; Metacognition; Middle Aged; Mindfulness; Motivation; Saliva; Social Behavior; Stress, Psychological; Young Adult
 Zusammenfassung: Brain-derived neurotrophic factor (BDNF) is an essential facilitator of neuronal plasticity. By counteracting the adverse effects of excessive stress-induced glucocorticoid signaling, BDNF has been implicated as a resilience factor to psychopathology caused by chronic stress. Insights into the effects of acute stress on peripheral BDNF levels in humans are inconclusive. The short-term interplay between BDNF and cortisol in response to acute psychosocial stress remains unexplored. Furthermore, it is unknown whether mental training that is effective at reducing cortisol reactivity can also influence BDNF during acute stress. In the current study, we investigated serum BDNF levels during an acute psychosocial stress paradigm, the Trier Social Stress Test (TSST), in 301 healthy participants (178 women, mean age = 40.65) recruited as part of the ReSource Project, a large-scale mental training study consisting of three distinct 3-month training modules. Using a cross-sectional study design, we first examined the relationship between BDNF and salivary cortisol in a control group with no mental training. Subsequent analyses focused on differences in BDNF stress levels between control and mental training groups. We show that serum BDNF is indeed stress-sensitive, characterized by a significant post-stress increase and subsequent decline to recovery. While respective increases in BDNF and cortisol were not associated, we found two indications for an antagonistic relationship. Higher BDNF peaks after stress were associated with steeper cortisol recovery. On the other hand, the magnitude of the cortisol stress response was linked to steeper BDNF recovery after stress. BDNF levels were not modulated by any of the mental training modules. Providing novel evidence for the dynamics of BDNF and cortisol during acute stress, our findings may further inform research on the physiological mechanisms involved in stress chronification and the associated health risks.

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Sprache(n): eng - English
 Datum: 2019-03-242018-11-232019-04-042019-04-162019-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41386-019-0391-y
PMID: 30991416
Anderer: Epub ahead of print
 Art des Abschluß: -

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Projektinformation

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Projektname : Plasticity of the Empathic Brain: Structural and Functional MRI Studies on the Effect of Empathy Training on the Human Brain and Prosocial Behaviour / EMPATHICBRAIN
Grant ID : 205557
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society

Quelle 1

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Titel: Neuropsychopharmacology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : No longer published by Elsevier
Seiten: - Band / Heft: 44 Artikelnummer: - Start- / Endseite: 1797 - 1804 Identifikator: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485