Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Lanthanide Complexes with 1H paraCEST and 19F Response for Magnetic Resonance Imaging Applications

Pujales-Paradela, R., Savić, T., Pérez-Lourido, P., Esteban-Gómez, D., Angelovski, G., Botta, M., et al. (2019). Lanthanide Complexes with 1H paraCEST and 19F Response for Magnetic Resonance Imaging Applications. Inorganic Chemistry, 58(11), 7571-7583. doi:10.1021/acs.inorgchem.9b00869.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Pujales-Paradela, R, Autor
Savić, T1, 2, Autor           
Pérez-Lourido, P, Autor
Esteban-Gómez, D, Autor
Angelovski, G1, 2, Autor           
Botta, M, Autor
Platas-Iglesias, C, Autor
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: We present a detailed study of the lanthanide(III) complexes with cyclen-based ligands containing phenylacetamide pendants that incorporate CF3 group(s) at different distances from the metal ion. The complexes exhibit square-antiprismatic coordination in solution, as demonstrated by analysis of the Yb3+-induced paramagnetic shifts and the X-ray structure of the [YbL3] complex. Luminescence lifetime measurements and a detailed 1H and 17O relaxometric characterization confirmed the presence of an inner-sphere H2O molecule. The Tm3+ complexes provide chemical-exchange saturation-transfer response upon saturation at the frequency of the amide protons. A 19F relaxation study provided accurate estimates of the Ln···F distances that were used to rationalize the efficiency of the complexes as 19F magnetic resonance imaging (MRI) probes, which was tested in vitro using MRI phantom studies.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2019-052019-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1021/acs.inorgchem.9b00869
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Inorganic Chemistry
  Kurztitel : Inorg. Chem.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, DC : American Chemical Society
Seiten: - Band / Heft: 58 (11) Artikelnummer: - Start- / Endseite: 7571 - 7583 Identifikator: ISSN: 0020-1669
CoNE: https://pure.mpg.de/cone/journals/resource/0020-1669