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  A fear memory engram and its plasticity in the hypothalamic oxytocin system

Hasan, M. T., Althammer, F., da Gouveia, M. S., Goyon, S., Eliava, M., Lefevre, A., et al. (2019). A fear memory engram and its plasticity in the hypothalamic oxytocin system. Neuron. doi:https://doi.org/10.1016/j.neuron.2019.04.029.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-A0EC-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A0ED-D
Genre: Journal Article

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 Creators:
Hasan, Mazahir T.1, 2, 3, Author              
Althammer, Ferdinand2, Author              
da Gouveia , Miriam Silva, Author
Goyon , Stephanie, Author
Eliava, Marina2, 4, Author              
Lefevre , Arthur, Author
Kerspern , Damien, Author
Schimmer , Jonas, Author
Raftogianni, Androniki2, Author              
Wahis , Jerome, Author
Knobloch, Sophie2, Author              
Tang , Yan, Author
Liu , Xinying, Author
Jain, Apar2, Author              
Chavant , Virginie, Author
Goumon , Yannick, Author
Weislogel , Jan-Marek, Author
Hurlemann , René, Author
Herpertz , Sabine C., Author
Pitzer , Claudia, Author
Darbon , Pascal, AuthorDogbevia, Godwin2, 3, 5, Author              Bertocchi, Ilaria2, 5, Author              Larkum, Matthew E.6, 7, Author              Sprengel, Rolf2, 5, 8, Author              Bading , Hilmar, AuthorCharlet , Alexandre, AuthorGrinevich, Valery2, 4, Author               more..
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Mazahir Hasan Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497726              
4Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497746              
5Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
6Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
7Cortical Circuits, Max Planck Institute for Medical Research, Max Planck Society, ou_1497694              
8Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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 Abstract: Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identified and permanently tagged a small subpopulation of OT cells, which, by optogenetic stimulation, strongly attenuated contextual fear-induced freezing, and pharmacogenetic silencing of tagged OT neurons impaired context-specific fear extinction, demonstrating that the tagged OT neurons are sufficient and necessary, respectively, to control contextual fear. Intriguingly, OT cell terminals of fear-experienced rats displayed enhanced glutamate release in the amygdala. Furthermore, rats exposed to another round of fear conditioning displayed 5-fold more activated magnocellular OT neurons in a novel environment than a familiar one, possibly for a generalized fear response. Thus, our results provide first evidence that hypothalamic OT neurons represent a fear memory engram.

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Language(s): eng - English
 Dates: 2019-05-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565