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  Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation

Fukuda, Y., Katthagen, T., Deserno, L., Shayegan, L., Kaminski, J., Heinz, A., et al. (2019). Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation. Journal of Psychiatry & Neuroscience, 44(3), 195-204. doi:10.1503/jpn.180043.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-AC11-8 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-056E-3
Genre: Zeitschriftenartikel

Externe Referenzen

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488486/ (Verlagsversion)
Beschreibung:
-
OA-Status:
Grün

Urheber

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 Urheber:
Fukuda, Yu 1, 2, Autor
Katthagen, Teresa 1, 2, Autor
Deserno, Lorenz3, 4, Autor           
Shayegan, Leila 5, Autor
Kaminski , Jakob1, 2, 3, Autor
Heinz, Andreas1, 2, Autor
Schlagenhauf, Florian1, 2, 3, Autor           
Affiliations:
1Charité University Medicine Berlin, Germany, ou_persistent22              
2Berlin Institute of Health (BIH), Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Germany, ou_persistent22              
5Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              

Inhalt

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Schlagwörter: Adult; Connectome; Delusions; Female; Humans; Magnetic Resonance Imaging; Male; Memory, Short-Term; Nerve Net; Parietal Lobe; Prefrontal Cortex; Young Adult
 Zusammenfassung: Background: Working-memory impairment is a core cognitive dysfunction in people with schizophrenia and people at mental high risk. Recent imaging studies on working memory have suggested that abnormalities in prefrontal activation and in connectivity between the frontal and parietal regions could be neural underpinnings of the different stages of psychosis. However, it remains to be explored whether comparable alterations are present in people with subclinical levels of psychosis, as experienced by a small proportion of the general population who neither seek help nor show constraints in daily functioning.

Methods: We compared 24 people with subclinical high delusional ideation and 24 people with low delusional ideation. Both groups performed an n-back working-memory task during functional magnetic resonance imaging. We characterized frontoparietal effective connectivity using dynamic causal modelling.

Results: Compared to people who had low delusional ideation, people with high delusional ideation showed a significant increase in dorsolateral prefrontal activation during the working-memory task, as well as reduced working-memory-dependent parietofrontal effective connectivity in the left hemisphere. Group differences were not evident at the behavioural level.

Limitations: The current experimental design did not distinguish among the working-memory subprocesses; it remains unexplored whether differences in connectivity exist at that level.

Conclusion: These findings suggest that alterations in the working-memory network are also present in a nonclinical population with psychotic experiences who do not display cognitive deficits. They also suggest that alterations in working-memory-dependent connectivity show a putative continuity along the spectrum of psychotic symptoms.

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Sprache(n): eng - English
 Datum: 2018-07-202018-03-202018-08-222019-01-152019-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1503/jpn.180043
PMID: 30657658
 Art des Abschluß: -

Veranstaltung

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Entscheidung

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Projektinformation

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Projektname : -
Grant ID : SCHL1969/1-1 ; SCHL1969/1-1-2 ; 1969/3-1 ; SCHL 1969/4-1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : GlaxoSmithKline Stiftung
Projektname : -
Grant ID : -
Förderprogramm : Elsa Neumann Scholarship
Förderorganisation : City of Berlin
Projektname : -
Grant ID : -
Förderprogramm : Fulbright Grant
Förderorganisation : German–American Fulbright Commission
Projektname : -
Grant ID : -
Förderprogramm : Berlin School of Mind and Brain postdoc scholarship
Förderorganisation : Berlin School of Mind and Brain
Projektname : -
Grant ID : -
Förderprogramm : Junior Clinician Scientist Track
Förderorganisation : Berliner Institut für Gesundheitsforschung (BIH)
Projektname : -
Grant ID : 01GQ0411 ; 01QG87164 ; NGFN Plus 01 GS 08152 ; 01 GS 08159
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)

Quelle 1

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Titel: Journal of Psychiatry & Neuroscience
  Kurztitel : J Psychiatry Neurosci
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Ottawa, Ont., Canada : Journal of Psychiatry and Neuroscience
Seiten: - Band / Heft: 44 (3) Artikelnummer: - Start- / Endseite: 195 - 204 Identifikator: ISSN: 1180-4882
CoNE: https://pure.mpg.de/cone/journals/resource/1180-4882