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  Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation

Fukuda, Y., Katthagen, T., Deserno, L., Shayegan, L., Kaminski, J., Heinz, A., et al. (2019). Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation. Journal of Psychiatry & Neuroscience, 44(3), 195-204. doi:10.1503/jpn.180043.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-AC11-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-056E-3
Genre: Journal Article

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Locator:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488486/ (Publisher version)
Description:
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OA-Status:
Green

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 Creators:
Fukuda, Yu 1, 2, Author
Katthagen, Teresa 1, 2, Author
Deserno, Lorenz3, 4, Author           
Shayegan, Leila 5, Author
Kaminski , Jakob1, 2, 3, Author
Heinz, Andreas1, 2, Author
Schlagenhauf, Florian1, 2, 3, Author           
Affiliations:
1Charité University Medicine Berlin, Germany, ou_persistent22              
2Berlin Institute of Health (BIH), Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Germany, ou_persistent22              
5Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              

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Free keywords: Adult; Connectome; Delusions; Female; Humans; Magnetic Resonance Imaging; Male; Memory, Short-Term; Nerve Net; Parietal Lobe; Prefrontal Cortex; Young Adult
 Abstract: Background: Working-memory impairment is a core cognitive dysfunction in people with schizophrenia and people at mental high risk. Recent imaging studies on working memory have suggested that abnormalities in prefrontal activation and in connectivity between the frontal and parietal regions could be neural underpinnings of the different stages of psychosis. However, it remains to be explored whether comparable alterations are present in people with subclinical levels of psychosis, as experienced by a small proportion of the general population who neither seek help nor show constraints in daily functioning.

Methods: We compared 24 people with subclinical high delusional ideation and 24 people with low delusional ideation. Both groups performed an n-back working-memory task during functional magnetic resonance imaging. We characterized frontoparietal effective connectivity using dynamic causal modelling.

Results: Compared to people who had low delusional ideation, people with high delusional ideation showed a significant increase in dorsolateral prefrontal activation during the working-memory task, as well as reduced working-memory-dependent parietofrontal effective connectivity in the left hemisphere. Group differences were not evident at the behavioural level.

Limitations: The current experimental design did not distinguish among the working-memory subprocesses; it remains unexplored whether differences in connectivity exist at that level.

Conclusion: These findings suggest that alterations in the working-memory network are also present in a nonclinical population with psychotic experiences who do not display cognitive deficits. They also suggest that alterations in working-memory-dependent connectivity show a putative continuity along the spectrum of psychotic symptoms.

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Language(s): eng - English
 Dates: 2018-07-202018-03-202018-08-222019-01-152019-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1503/jpn.180043
PMID: 30657658
 Degree: -

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Project name : -
Grant ID : SCHL1969/1-1 ; SCHL1969/1-1-2 ; 1969/3-1 ; SCHL 1969/4-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : -
Funding program : -
Funding organization : GlaxoSmithKline Stiftung
Project name : -
Grant ID : -
Funding program : Elsa Neumann Scholarship
Funding organization : City of Berlin
Project name : -
Grant ID : -
Funding program : Fulbright Grant
Funding organization : German–American Fulbright Commission
Project name : -
Grant ID : -
Funding program : Berlin School of Mind and Brain postdoc scholarship
Funding organization : Berlin School of Mind and Brain
Project name : -
Grant ID : -
Funding program : Junior Clinician Scientist Track
Funding organization : Berliner Institut für Gesundheitsforschung (BIH)
Project name : -
Grant ID : 01GQ0411 ; 01QG87164 ; NGFN Plus 01 GS 08152 ; 01 GS 08159
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

Source 1

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Title: Journal of Psychiatry & Neuroscience
  Abbreviation : J Psychiatry Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Ottawa, Ont., Canada : Journal of Psychiatry and Neuroscience
Pages: - Volume / Issue: 44 (3) Sequence Number: - Start / End Page: 195 - 204 Identifier: ISSN: 1180-4882
CoNE: https://pure.mpg.de/cone/journals/resource/1180-4882