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  A genomics approach reveals insights into the importance of gene losses for mammalian adaptations.

Sharma, V., Hecker, N., Roscito, J., Foerster, L., Langer, B., & Hiller, M. (2018). A genomics approach reveals insights into the importance of gene losses for mammalian adaptations. Nature communications, 9(1): 1215. doi:10.1038/s41467-018-03667-1.

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Sharma, Virag1, Author           
Hecker, Nikolai1, Author           
Roscito, Juliana1, Author           
Foerster, Leo, Author
Langer, Björn1, Author           
Hiller, Michael1, Author           
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in evolutionary biology and genomics. Loss of protein-coding genes is one type of genomic change with the potential to affect phenotypic evolution. Here, we develop a genomics approach to accurately detect gene losses and investigate their importance for adaptive evolution in mammals. We discover a number of gene losses that likely contributed to morphological, physiological, and metabolic adaptations in aquatic and flying mammals. These gene losses shed light on possible molecular and cellular mechanisms that underlie these adaptive phenotypes. In addition, we show that gene loss events that occur as a consequence of relaxed selection following adaptation provide novel insights into species' biology. Our results suggest that gene loss is an evolutionary mechanism for adaptation that may be more widespread than previously anticipated. Hence, investigating gene losses has great potential to reveal the genomic basis underlying macroevolutionary changes.

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 Dates: 2018-03-23
 Publication Status: Issued
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 Identifiers: DOI: 10.1038/s41467-018-03667-1
Other: cbg-7077
PMID: 29572503
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Title: Nature communications
  Other : Nat Commun
Source Genre: Journal
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Pages: - Volume / Issue: 9 (1) Sequence Number: 1215 Start / End Page: - Identifier: -