English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Early childhood

Kaschube, M., Nelson III, C. A., Benasich, A. A., Buzsáki, G., Gressens, P., Hensch, T. K., et al. (2018). Early childhood. In A. A. Benasich, & U. Ribary (Eds.), Emergent Brain Dynamics: Prebirth to Adolescence (pp. 101-123). Cambridge, MA: MIT Press.

Item is

Files

show Files
hide Files
:
SFR25_07_Kaschube GR.pdf (Any fulltext), 884KB
Name:
SFR25_07_Kaschube GR.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Kaschube, Matthias, Author
Nelson III, C. A., Author
Benasich, A. A., Author
Buzsáki, G., Author
Gressens, P., Author
Hensch, T. K., Author
Hübener, Mark1, Author           
Kobor, M. S., Author
Singer, Wolf, Author
Sur, M., Author
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

Content

show
hide
Free keywords: -
 Abstract: During the first years after birth, infants face the enormous task of building a compre-
hensive and predictive internal model of the external world, allowing them to navigate
and interact successfully with their environment. This chapter explores the frontiers involved in understanding the neural bases of this process and how such knowledge could be leveraged to treat and prevent neurodevelopmental disorders. It begins by describing how developing brains form dynamical networks that integrate genetic, epigenetic, and sensory information, emphasizing the interplay between molecules and neural activity.
Strategies are highlighted that the brain uses to tightly control the impact of sensory input onto its developing networks, which are manifest at the molecular, neural activity, and behavioral levels, and which appear pivotal as the brain strives to maintain a fine balance of flexible yet stable configuration. While suitable animal models have greatly contributed to our basic understanding of neural development, revealing the neural basis of cognitive development in humans remains a challenge. To overcome this barrier, new directions are discussed that combine animal and human studies. Finally, this chapter discusses implications of the complexity of the human brain and highlights the potential of data-driven formal models of neurodevelopmental trajectories to enable early detection and individualized treatment of developmental disorders.

Details

show
hide
Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Emergent Brain Dynamics: Prebirth to Adolescence
  Other : Strüngmann Forum Reports
Source Genre: Book
 Creator(s):
Benasich, A. A., Editor
Ribary, Urs, Editor
Affiliations:
-
Publ. Info: Cambridge, MA : MIT Press
Pages: - Volume / Issue: 25 Sequence Number: - Start / End Page: 101 - 123 Identifier: ISBN: 9780262038638