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  Interaction of sex and age on the dissociative effects of ketamine action in young healthy participants

Derntl, B., Hornung, J., Sen, Z., Colic, L., Li, M., & Walter, M. (2019). Interaction of sex and age on the dissociative effects of ketamine action in young healthy participants. Frontiers in Neuroscience, 13: 616, pp. 1-8. doi:10.3389/fnins.2019.00616.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-B709-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D67C-1
Genre: Journal Article

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 Creators:
Derntl, B, Author
Hornung, J, Author
Sen, ZD, Author
Colic, L, Author
Li, M1, 2, Author              
Walter, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Ketamine is a drug that reduces depressive and elicits schizophrenia-like symptoms in humans. However, it is largely unexplored whether women and men differ with respect to ketamine-action and whether age contributes to drug-effects. In this study we assessed dissociative symptoms via the Clinician Administered Dissociative States Scale (CADSS) in a total of 69 healthy subjects aged between 18-30 years (early adulthood) after ketamine or placebo infusion. Dissociative symptoms were generally increased only in the ketamine group post-infusion. Specifically, within the ketamine group, men reported trendwise more amnestic symptoms than women. Furthermore, with rising age only men were less affected overall with respect to dissociative symptoms. This suggests a sex-specific protective effect of higher age which may be due to delayed brain maturation in men compared to women. We conclude that it is crucial to include sex and age in studies of drug effects in general and of ketamine-action in specific to tailor more efficient psychiatric drug-treatments.

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 Dates: 2019-052019-06
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fnins.2019.00616
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 616 Start / End Page: 1 - 8 Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548