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  Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán

Ballesteros-Romero, M., Barquera, R., Rodríguez-López, M. E., Hernández-Zaragoza, D. I., Goné-Vázquez, I., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán. Human Immunology. doi:10.1016/j.humimm.2019.05.017.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-BE7C-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BE90-4
Genre: Journal Article

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 Creators:
Ballesteros-Romero, Mónica, Author
Barquera, Rodrigo1, Author              
Rodríguez-López, Marla Estefanía, Author
Hernández-Zaragoza, Diana Iraíz, Author
Goné-Vázquez, Isis, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
Escobedo-Ruíz, Araceli, Author
Pantoja-Torres, Jorge Arturo, Author
García-Arias, Víctor Eduardo, Author
Arellano-Prado, Francia Paulina, Author
Bravo-Acevedo, Alicia, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Sandoval-Sandoval, Mario J., Author
Gómez-Navarro, Benjamín, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Acuña-Alonzo, Víctor, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Michoacán, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 498 Mexicans from the state of Michoacán living in the city of Morelia (N = 150) and rural communities (N = 348), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Michoacán include 12 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Michoacán are Native American (48.79 ± 1.44) and European (43.10 ± 0.86), while African genetic component is less apparent (8.11 ± 0.85). Our findings add to the growing knowledge on the population genetics of Western Mexico and provide new HLA data on populations from Michoacán.

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Language(s): eng - English
 Dates: 2019-06-04
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.05.017
Other: shh2243
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912