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  Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonalá, Zapopan and rural Jalisco

Bravo-Acevedo, A., Escobedo-Ruíz, A., Barquera, R., Clayton, S., García-Arias, V. E., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonalá, Zapopan and rural Jalisco. Human Immunology, 2019.05.012. doi:10.1016/j.humimm.2019.05.012.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-BE86-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-A138-5
Genre: Journal Article

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Bravo-Acevedo, Alicia, Author
Escobedo-Ruíz, Araceli, Author
Barquera, Rodrigo1, Author              
Clayton, Stephen1, Author              
García-Arias, Víctor Eduardo, Author
Arrieta-Bolaños, Esteban, Author
Goné-Vázquez, Isis, Author
Hernández-Zaragoza, Diana Iraíz, Author
Arellano-Prado, Francia Paulina, Author
Rodríguez-López, Marla Estefanía, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Sandoval-Sandoval, Mario J., Author
Gómez-Navarro, Benjamín, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Jalisco, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2046 Mexicans from the state of Jalisco living in the city of Guadalajara (N = 1189), Tlajomulco (N = 30), Tlaquepaque (N = 39), Tonalá (N = 35), Zapopan (N = 168) and rural communities (N = 585), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Jalisco include nine Native American most probable ancestry and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Jalisco are European (48.45 ± 1.18 by ML; 41.66 of European haplotypes) and Native American (44.02 ± 1.24 by ML; 39.86 of Native American haplotypes), while African genetic component is less apparent (7.53 ± 0.30 by ML; 9.62 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-04
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.05.012
Other: shh2244
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: 2019.05.012 Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912