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  Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obregón, Hermosillo and rural Sonora

Uribe-Duarte, M. G., Aguilar-Campos, J. A., Barquera, R., Bravo-Acevedo, A., Clayton, S., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obregón, Hermosillo and rural Sonora. Human Immunology, 2019.05.013. doi:10.1016/j.humimm.2019.05.013.

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Uribe-Duarte, María Guadalupe, Author
Aguilar-Campos, Jesús Abraham, Author
Barquera, Rodrigo1, Author              
Bravo-Acevedo, Alicia, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
de Ruíz-Corral, María Jesús, Author
Hernández-Zaragoza, Diana Iraíz, Author
Serrano-Osuna, Ricardo, Author
Yunis, Edmond J., Author
Zúñiga, Joaquín, Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
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1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Sonora, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 439 Mexicans from the state of Sonora living in Ciudad Obregón (N = 143), Hermosillo (N = 99), and rural communities (N = 197) to obtain information regarding allelic and haplotypic frequencies. We find that the 13 most frequent haplotypes for the state of Sonora include nine Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Sonora are European (51.25 ± 2.90 by ML; 37.70 of European haplotypes) and Native American (43.35 ± 2.57 by ML; 39.64 of Native American haplotypes), while the African genetic component was less apparent (5.39 ± 2.54 by ML; 11.04 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-04
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.05.013
Other: shh2245
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: 2019.05.013 Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912