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  A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., et al. (2019). A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature Immunology, 20(4), 493-502. doi:10.1038/s41590-019-0323-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-DE15-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-DE16-B
Genre: Journal Article

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 Creators:
Hubel, Philipp1, Author              
Urban, Christian2, Author
Bergant, Valter2, Author
Schneider, William M.2, Author
Knauer, Barbara1, Author              
Stukalov, Alexey1, Author              
Scaturro, Pietro1, Author              
Mann, Angelika1, Author              
Brunotte, Linda2, Author
Hoffmann, Heinrich H.2, Author
Schoggins, John W.2, Author
Schwemmle, Martin2, Author
Mann, Matthias3, Author              
Rice, Charles M.2, Author
Pichlmair, Andreas1, Author              
Affiliations:
1Pichlmair, Andreas / Innate Immunity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565166              
2external, ou_persistent22              
3Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: COMPUTATIONAL PLATFORM; RECEPTOR; REVEALS; COMPLEX; TARGET; CELLSImmunology;
 Abstract: Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: We thank ... the MPI-B core facility for support.
 Rev. Method: -
 Identifiers: ISI: 000461904200019
DOI: 10.1038/s41590-019-0323-3
 Degree: -

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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 20 (4) Sequence Number: - Start / End Page: 493 - 502 Identifier: ISSN: 1529-2908
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073