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  Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

Niu, L., Geyer, P. E., Albrechtsen, N. J. W., Gluud, L. L., Santos, A., Doll, S., et al. (2019). Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease. Molecular Systems Biology, 15(3): e8793. doi:10.15252/msb.20188793.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-DE45-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-DE46-5
Genre: Journal Article

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 Creators:
Niu, Lili1, Author
Geyer, Philipp E.2, Author              
Albrechtsen, Nicolai J. Wewer2, Author              
Gluud, Lise L.1, Author
Santos, Alberto1, Author
Doll, Sophia2, Author              
Treit, Peter V.2, Author              
Holst, Jens J.1, Author
Knop, Filip K.1, Author
Vilsbol, Tina1, Author
Junker, Anders1, Author
Sachs, Stephan1, Author
Stemmer, Kerstin1, Author
Mueller, Timo D.1, Author
Tschoep, Matthias H.1, Author
Hofmann, Susanna M.1, Author
Mann, Matthias2, Author              
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: DIPEPTIDYL PEPTIDASE-4; BIOMARKER DISCOVERY; INSULIN-RESISTANCE; FIBROSIS; STEATOHEPATITIS; GALECTIN-3; NASH; SITAGLIPTIN; CIRRHOSIS; OBESITYBiochemistry & Molecular Biology; biomarker discovery; mass spectrometry; NAFLD; NASH; plasma proteome profiling;
 Abstract: Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma proteome profiling of 48 patients with and without cirrhosis or NAFLD revealed six statistically significantly changing proteins (ALDOB, APOM, LGALS3BP, PIGR, VTN, and AFM), two of which are already linked to liver disease. Polymeric immunoglobulin receptor (PICR) was significantly elevated in both cohorts by 170% in NAFLD and 298% in cirrhosis and was further validated in mouse models. Furthermore, a global correlation map of clinical and proteomic data strongly associated DPP4, ANPEP, TGFBI, PIGR, and APOE with NAFLD and cirrhosis. The prominent diabetic drug target DPP4 is an aminopeptidase like ANPEP, ENPEP, and LAP3, all of which are up-regulated in the human or mouse data. Furthermore, ANPEP and TGFBI have potential roles in extracellular matrix remodeling in fibrosis. Thus, plasma proteome profiling can identify potential biomarkers and drug targets in liver disease.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000463969600006
DOI: 10.15252/msb.20188793
 Degree: -

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Project name : Challenge Programme MicrobLiver (Grant No. NNF15OC0016692)
Grant ID : NNF15OC0016692
Funding program : -
Funding organization : Novo Nordisk Foundation
Project name : MSmed project
Grant ID : 686547
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Molecular Systems Biology
Source Genre: Journal
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Publ. Info: London : Nature Pub. Group
Pages: - Volume / Issue: 15 (3) Sequence Number: e8793 Start / End Page: - Identifier: ISSN: 1744-4292
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290