English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Sakaguchi, M., Cai, W., Wang, C.-H., Cederquist, C. T., Damasio, M., Homan, E. P., et al. (2019). FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications, 10: 1582. doi:10.1038/s41467-019-09418-0.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
s41467-019-09418-0.pdf (Publisher version), 5MB
Name:
s41467-019-09418-0.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
Open Access
:
41467_2019_9418_MOESM1_ESM.pdf (Supplementary material), 5MB
Name:
41467_2019_9418_MOESM1_ESM.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Sakaguchi, Masaji1, Author
Cai, Weikang1, Author
Wang, Chih-Hao1, Author
Cederquist, Carly T.1, Author
Damasio, Marcos1, Author
Homan, Erica P.1, Author
Batista, Thiago1, Author
Ramirez, Alfred K.1, Author
Gupta, Manoj K.1, Author
Steger, Martin2, Author              
Albrechtsen, Nicolai J. Wewer2, Author              
Singh, Shailendra Kumar1, Author
Araki, Eiichi1, Author
Mann, Matthias2, Author              
Enerback, Sven1, Author
Kahn, C. Ronald1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Content

show
hide
Free keywords: TRANSCRIPTION FACTOR FOXO1; BINDING PROTEIN-1C SREBP-1C; GENE-EXPRESSION; IGF-1 RECEPTORS; DIFFERENTIAL ROLES; GLUCOSE; GROWTH; BETA; MICE; FKHRScience & Technology - Other Topics;
 Abstract: A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Knockdown of FoxK1 and FoxK2 in liver cells results in upregulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipid metabolism. This is associated with decreased cell proliferation and altered mitochondrial fatty acid metabolism. Thus, FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.

Details

show
hide
Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 1582 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723