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  Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa

Clayton, S., Barquera, R., Uribe-Duarte, M. G., Vázquez, I. G., Zúñiga, J., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa. Human Immunology. doi:10.1016/j.humimm.2019.06.006.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C3D9-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C3DA-B
Genre: Journal Article

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 Creators:
Clayton, Stephen1, Author              
Barquera, Rodrigo1, Author              
Uribe-Duarte, María Guadalupe, Author
Vázquez, Isis Goné, Author
Zúñiga, Joaquín, Author
Arrieta-Bolaños, Esteban, Author
Hernández-Zaragoza, Diana Iraíz, Author
de Ruíz-Corral, María Jesús, Author
Escobedo-Ruíz, Araceli, Author
Arellano-Prado, Francia Paulina, Author
García-Arias, Víctor Eduardo, Author
Rodríguez-López, Marla Estefanía, Author
Bravo-Acevedo, Alicia, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Aguilar-Campos, Jesús Abraham, Author
Serrano-Osuna, Ricardo, Author
Gómez-Navarro, Benjamín, Author
Sandoval-Sandoval, Mario J., Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Sinaloa, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47) and Native American (37.61 ± 2.85), while the African genetic component was estimated as virtually absent (0.00 ± 1.86).

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Language(s): eng - English
 Dates: 2019-06-12
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.006
Other: shh2249
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912