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  Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit

Goné-Vázquez, I., Barquera, R., Arellano-Prado, F. P., Hernández-Zaragoza, D. I., Escobedo-Ruíz, A., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit. Human Immunology. doi:10.1016/j.humimm.2019.06.008.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C3F0-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C3F1-0
Genre: Journal Article

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Goné-Vázquez, Isis, Author
Barquera, Rodrigo1, Author              
Arellano-Prado, Francia Paulina, Author
Hernández-Zaragoza, Diana Iraíz, Author
Escobedo-Ruíz, Araceli, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
García-Arias, Víctor Eduardo, Author
Rodríguez-López, Marla Estefanía, Author
Bravo-Acevedo, Alicia, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Sandoval-Sandoval, Mario J., Author
Gómez-Navarro, Benjamín, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Nayarit, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 161 Mexicans from the state of Nayarit living in Tepic (N = 97) and rural communities (N = 64), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Nayarit include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nayarit are Native American (50.79 ± 5.03 by ML; 42.24 of Native American haplotypes) and European (37.04 ± 6.21 by ML; 35.72 of European haplotypes), while African genetic component is less apparent but relatively high (12.17 ± 2.50 by ML; 13.36 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-11
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.008
Other: shh2251
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912