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  Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León

Barquera, R., Bravo-Acevedo, A., Clayton, S., Munguía, T. J. R., Hernández-Zaragoza, D. I., Adalid-Sáinz, C., et al. (2019). Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León. Human Immunology, 2019.06.003. doi:10.1016/j.humimm.2019.06.003.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C402-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-A150-9
Genre: Journal Article

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 Creators:
Barquera, Rodrigo1, Author              
Bravo-Acevedo, Alicia, Author
Clayton, Stephen1, Author              
Munguía, Tirzo Jesús Rodríguez, Author
Hernández-Zaragoza, Diana Iraíz, Author
Adalid-Sáinz, Carmen, Author
Arrieta-Bolaños, Esteban, Author
Aquino-Rubio, Guadalupe, Author
González-Martínez, Marisela del Rocío, Author
Lona-Sánchez, Abraham, Author
Martínez-Álvarez, Julio César, Author
Arrazola-García, María Araceli, Author
Delgado-Aguirre, Héctor, Author
González-Medina, Liliana, Author
Pacheco-Ubaldo, Hanna, Author
Juárez-Barreto, Vicencio, Author
Benítez-Arvizu, Gamaliel, Author
Escareño-Montiel, Néstor, Author
la Cruz, Federico Juárez-de, Author
Jaramillo-Rodríguez, Yolanda, Author
Salgado-Adame, Antonio, AuthorZúñiga, Joaquín, AuthorYunis, Edmond J., AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Nuevo León, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo León living in the city of Monterrey (N = 226) and rural communities (N = 439), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Nuevo León include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nuevo León are Native American (54.53 ± 0.87 by ML; 48.88 of Native American haplotypes) and European (38.67 ± 4.06 by ML; 32.59 of European haplotypes), and a less prominent African genetic component (6.80 ± 4.30 by ML; 8.26 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-11
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.003
Other: shh2252
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: 2019.06.003 Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912