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  Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua

Pacheco-Ubaldo, H., Adalid-Sáinz, C., Barquera, R., Clayton, S., Arrieta-Bolaños, E., Delgado-Aguirre, H., et al. (2019). Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua. Human Immunology, 2019.05.014. doi:10.1016/j.humimm.2019.05.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C418-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-A151-8
Genre: Journal Article

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Pacheco-Ubaldo, Hanna, Author
Adalid-Sáinz, Carmen, Author
Barquera, Rodrigo1, Author              
Clayton, S.1, Author              
Arrieta-Bolaños, Esteban, Author
Delgado-Aguirre, Héctor, Author
González-Medina, Liliana, Author
Hernández-Zaragoza, Diana Iraíz, Author
Escareño-Montiel, Néstor, Author
Morán-Martínez, Javier, Author
Bravo-Acevedo, Alicia, Author
Lona-Sánchez, Abraham, Author
González-Martínez, Marisela del Rocío, Author
Jaramillo-Rodríguez, Yolanda, Author
Salgado-Adame, Antonio, Author
la Cruz, Federico Juárez-de, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Chihuahua, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N = 119), Ciudad Juárez (N = 106) and rural communities (N = 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 ± 0.88 by ML; 41.53 of European haplotypes) and Native American (39.51 ± 2.17 by ML; 37.45 of Native American haplotypes), while African genetic component was less apparent (8.36 ± 1.47 by ML; 11.70 of African haplotypes).

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 Dates: 2019-06-04
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.05.014
Other: shh2253
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: 2019.05.014 Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912