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  Genetic architecture of subcortical brain structures in 38,854 individuals worldwide

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., et al. (2019). Genetic architecture of subcortical brain structures in 38,854 individuals worldwide. Nature Genetics, 51, 1624-1636. doi:10.1038/s41588-019-0511-y.

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 Creators:
Satizabal, Claudia L.1, 2, 3, 4, Author
Adams, Hieab H. H.5, 6, Author
Hibar, Derrek P.7, Author
White, Charles C.8, 9, 10, Author
Knol, Maria J.5, Author
Stein, Jason L.7, 11, 12, Author
Scholz, Markus13, 14, Author
Sargurupremraj, Murali15, Author
Jahanshad, Neda7, Author
Roshchupkin, Gennady V.6, 16, Author
Smith, Albert V.17, 18, 19, Author
Bis, Joshua C.20, Author
Jian, Xueqiu21, Author
Luciano, Michelle22, Author
Hofer, Edith23, 24, Author
Teumer, Alexander25, Author
Van der Lee, Sven J.5, Author
Yang, Jingyun26, 27, Author
Yanek, Lisa R.28, Author
Lee, Tom V.29, Author
Li, Shuo30, AuthorHu, Yanhui31, AuthorKoh, Jia Yu32, AuthorEicher, John D.33, AuthorDesrivières, Sylvane34, AuthorArias-Vasquez, Alejandro35, 36, 37, 38, AuthorChauhan, Ganesh15, 39, AuthorAthanasiu, Lavinia40, 41, AuthorRenteria, Miguel E.42, AuthorKim, Sungeun43, 44, 45, AuthorHöhn, David46, AuthorArmstrong, Nicola J.47, AuthorChen, Qiang48, AuthorHolmes, Avram J.49, 50, AuthorDen Braber, Anouk51, AuthorKloszewska, Iwona52, AuthorAndersson, Micael53, 54, AuthorEspeseth, Thomas40, 55, AuthorGrimm, Oliver56, AuthorAbramovic, Lucija57, AuthorAlhusaini, Saud58, 59, AuthorMilaneschi, Yuri60, AuthorPapmeyer, Martina61, 62, AuthorAxelsson, Tomas63, AuthorEhrlich, Stefan50, 64, 65, AuthorRoiz-Santiañez, Roberto66, 67, 68, AuthorKraemer, Bernd69, AuthorHåberg, Asta K.70, 71, AuthorJones, Hannah J.72, 73, 74, AuthorPike, G. Bruce75, 76, AuthorStein, Dan J.77, 78, AuthorStevens, Allison65, AuthorBralten, Janita36, 38, AuthorVernooij, Meike W.5, 6, AuthorHarris, Tamara B.79, AuthorFilippi, Irina80, 81, 82, AuthorWitte, A. Veronica83, 84, AuthorGuadalupe, Tulio85, 86, Author           Wittfeld, Katharina87, 88, AuthorMosley, Thomas H.89, AuthorBecker, James T.90, 91, 92, AuthorDoan, Nhat Trung41, AuthorHagenaars, Saskia P.22, AuthorSaba, Yasaman93, AuthorCuellar-Partida, Gabriel94, AuthorAmin, Najaf5, AuthorHilal, Saima95, 96, AuthorNho, Kwangsik43, 44, 45, AuthorKarbalai, Nazanin46, AuthorArfanakis, Konstantinos26, 97, 98, AuthorBecker, Diane M.28, AuthorAmes, David99, 100, AuthorGoldman, Aaron L.48, AuthorLee, Phil H.50, 101, 102, 103, 104, AuthorBoomsma, Dorret I.51, AuthorLovestone, Simon105, 106, AuthorGiddaluru, Sudheer107, 108, AuthorLe Hellard, Stephanie107, 108, AuthorMattheisen, Manuel109, 110, 111, 112, 113, AuthorBohlken, Marc M.57, AuthorKasperaviciute, Dalia114, 115, AuthorSchmaal, Lianne60, 116, 117, AuthorLawrie, Stephen M.61, AuthorAgartz, Ingrid41, 112, 118, AuthorWalton, Esther64, 73, AuthorTordesillas-Gutierrez, Diana68, 119, AuthorDavies, Gareth E.120, AuthorShin, Jean121, AuthorIpser, Jonathan C.77, AuthorVinke, Louis N.122, AuthorHoogman, Martine36, 38, AuthorJia, Tianye34, AuthorBurkhardt, Ralph14, 123, AuthorKlein, Marieke36, 38, AuthorCrivello, Fabrice124, AuthorJanowitz, Deborah87, AuthorCarmichael, Owen125, AuthorHaukvik, Unn K.126, 127, AuthorAribisala, Benjamin S.128, 129, AuthorSchmidt, Helena93, AuthorStrike, Lachlan T.94, 130, AuthorCheng, Ching-Yu32, 131, AuthorRisacher, Shannon L.44, 45, AuthorPütz, Benno46, AuthorFleischman, Debra A.26, 27, 132, AuthorAssareh, Amelia A.133, AuthorMattay, Venkata S.48, 134, 135, AuthorBuckner, Randy L.50, 136, AuthorMecocci, Patrizia137, AuthorDale, Anders M.138, 139, 140, 141, 142, AuthorCichon, Sven143, 144, 145, AuthorBoks, Marco P.57, AuthorMatarin, Mar114, 146, 147, AuthorPenninx, Brenda W. J. H.60, AuthorCalhoun, Vince D.148, 149, AuthorChakravarty, M. Mallar150, 151, AuthorMarquand, Andre38, 152, AuthorMacare, Christine34, AuthorMasouleh, Shahrzad Kharabian83, 153, AuthorOosterlaan, Jaap154, 155, 156, AuthorAmouyel, Philippe157, 158, AuthorHegenscheid, Katrin159, AuthorRotter, Jerome I.160, AuthorSchork, Andrew J.139, 161, AuthorLiewald, David C. M.22, AuthorDe Zubicaray, Greig I. 162, 163, AuthorWong, Tien Yin32, 131, AuthorShen, Li43, 44, 45, AuthorSämann, Philipp G.46, AuthorBrodaty, Henry133, 164, AuthorRoffman, Joshua L.50, AuthorDe Geus, Eco J. C. 51, AuthorTsolaki, Magda165, AuthorErk, Susanne166, AuthorVan Eijk, Kristel R.167, AuthorCavalleri, Gianpiero L.168, AuthorVan der Wee, Nic J. A.169, 170, AuthorMcIntosh, Andrew M.22, 61, AuthorGollub, Randy L.50, 65, 101, AuthorBulayeva, Kazima B.171, AuthorBernard, Manon121, AuthorRichards, Jennifer S.35, 38, 172, AuthorHimali, Jayandra J.3, 4, 30, AuthorLoeffler, Markus13, 14, AuthorRommelse, Nanda37, 38, 173, AuthorHoffmann, Wolfgang88, 174, AuthorWestlye, Lars T.40, 175, AuthorValdés Hernández, Maria C. 128, 176, AuthorHansell, Narelle K.94, 130, AuthorVan Erp, Theo G. M. 177, AuthorWolf, Christiane178, AuthorKwok, John B. J.179, 180, 181, AuthorVellas, Bruno182, 183, AuthorHeinz, Andreas184, AuthorOlde Loohuis, Loes M. 185, AuthorDelanty, Norman59, 186, AuthorHo, Beng-Choon187, AuthorChing, Christopher R. K.7, 188, AuthorShumskaya, Elena36, 38, 152, AuthorSingh, Baljeet189, AuthorHofman, Albert5, 190, AuthorVan der Meer, Dennis 41, 191, AuthorHomuth, Georg192, AuthorPsaty, Bruce M.20, 193, 194, AuthorBastin, Mark128, 176, AuthorMontgomery, Grant W.94, AuthorForoud, Tatiana M.45, 195, AuthorReppermund, Simone133, 196, AuthorHottenga, Jouke-Jan51, AuthorSimmons, Andrew197, 198, 199, AuthorMeyer-Lindenberg, Andreas56, AuthorCahn, Wiepke57, AuthorWhelan, Christopher D.7, 59, AuthorVan Donkelaar, Marjolein M. J.36, 38, Author           Yang, Qiong30, AuthorHosten, Norbert159, AuthorGreen, Robert C.101, 200, AuthorThalamuthu, Anbupalam133, AuthorMohnke, Sebastian166, AuthorHulshoff Pol, Hilleke E. 57, AuthorLin, Honghuang3, 201, AuthorJack Jr., Clifford R.202, AuthorSchofield, Peter R.180, 203, AuthorMühleisen, Thomas W.145, 204, AuthorMaillard, Pauline189, AuthorPotkin, Steven G.177, AuthorWen, Wei133, AuthorFletcher, Evan189, AuthorToga, Arthur W.205, AuthorGruber, Oliver69, AuthorHuentelman, Matthew206, AuthorSmith, George Davey73, AuthorLauner, Lenore J.79, AuthorNyberg, Lars53, 207, 208, AuthorJönsson, Erik G.41, 112, AuthorCrespo-Facorro, Benedicto67, 68, AuthorKoen, Nastassja77, 78, AuthorGreve, Douglas65, 209, AuthorUitterlinden, André G.5, 210, AuthorWeinberger, Daniel R.48, 134, 211, 212, 213, AuthorSteen, Vidar M.107, 108, AuthorFedko, Iryna O.214, AuthorGroenewold, Nynke A.77, AuthorNiessen, Wiro J.6, 16, 215, AuthorToro, Roberto216, AuthorTzourio, Christophe15, AuthorLongstreth Jr., William T. 217, 218, AuthorIkram, M. Kamran5, 131, AuthorSmoller, Jordan W.50, 101, 103, 104, AuthorVan Tol, Marie-Jose 219, AuthorSussmann, Jessika E.61, AuthorPaus, Tomas220, AuthorLemaître, Hervé80, AuthorSchroeter, Matthias L.221, AuthorMazoyer, Bernard124, AuthorAndreassen, Ole A.40, 41, AuthorHolsboer, Florian46, 222, AuthorDepondt, Chantal223, AuthorVeltman, Dick J.60, AuthorTurner, Jessica A.149, 224, AuthorPausova, Zdenka121, AuthorSchumann, Gunter34, AuthorVan Rooij, Daan 35, 38, 225, AuthorDjurovic, Srdjan107, 226, AuthorDeary, Ian J.22, AuthorMcMahon, Katie L.227, AuthorMüller-Myhsok, Bertram46, 228, 229, AuthorBrouwer, Rachel M.57, AuthorSoininen, Hilkka230, 231, AuthorPandolfo, Massimo223, AuthorWassink, Thomas H.187, AuthorCheung, Joshua W.7, AuthorWolfers, Thomas36, 38, AuthorMartinot, Jean-Luc80, AuthorZwiers, Marcel P.38, 152, AuthorNauck, Matthias232, 233, AuthorMelle, Ingrid40, 41, AuthorMartin, Nicholas G.94, AuthorKanai, Ryota234, 235, 236, AuthorWestman, Eric237, AuthorKahn, René S.57, AuthorSisodiya, Sanjay M.114, AuthorWhite, Tonya6, 238, AuthorSaremi, Arvin7, AuthorVan Bokhoven, Hans36, 38, AuthorBrunner, Han G.36, 38, 239, 240, AuthorVölzke, Henry25, 233, AuthorWright, Margaret J.130, 227, AuthorVan 't Ent, Dennis 51, AuthorNöthen, Markus M.144, 241, AuthorOphoff, Roel A.57, 185, AuthorBuitelaar, Jan K.35, 38, 173, AuthorFernández, Guillén35, 38, AuthorSachdev, Perminder S.133, 242, AuthorRietschel, Marcella56, AuthorVan Haren, Neeltje E. M.57, AuthorFisher, Simon E.38, 86, Author           Beiser, Alexa S.3, 4, 30, AuthorFrancks, Clyde38, 86, 243, Author           Saykin, Andrew J.44, 45, 195, AuthorMather, Karen A.133, AuthorRomanczuk-Seiferth, Nina184, AuthorHartman, Catharina A.225, AuthorDeStefano, Anita L.3, 30, AuthorHeslenfeld, Dirk J.244, AuthorWeiner, Michael W.245, 246, AuthorWalter, Henrik166, AuthorHoekstra, Pieter J.225, AuthorNyquist, Paul A.28, AuthorFranke, Barbara36, 37, 38, AuthorBennett, David A.26, 27, AuthorGrabe, Hans J.87, 88, AuthorJohnson, Andrew D.33, AuthorChen, Christopher95, 96, AuthorVan Duijn, Cornelia M.5, 247, AuthorLopez, Oscar L.91, 92, AuthorFornage, Myriam248, 249, AuthorWardlaw, Joanna A.22, 176, 250, AuthorSchmidt, Reinhold23, AuthorDeCarli, Charles251, AuthorDe Jager, Philip L.10, 252, AuthorVillringer, Arno83, 84, AuthorDebette, Stéphanie15, AuthorGudnason, Vilmundur18, 19, AuthorMedland, Sarah E.94, AuthorShulman, Joshua M.29, 253, 254, 255, 256, AuthorThompson, Paul M.7, AuthorSeshadri, Sudha1, 3, 4, AuthorIkram, M. Arfan5, 6, Author more..
Affiliations:
1Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA, ou_persistent22              
2Department of Epidemiology and Biostatistics, UT Health San Antonio, San Antonio, TX, USA, ou_persistent22              
3The Framingham Heart Study, Framingham, MA, USA, ou_persistent22              
4Department of Neurology, Boston University School of Medicine, Boston, MA, USA, ou_persistent22              
5Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, ou_persistent22              
6Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands, ou_persistent22              
7Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, ou_persistent22              
8Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA, ou_persistent22              
9Institute for the Neurosciences, Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, USA, ou_persistent22              
10Medical and Population Genetics, Broad Institute, Cambridge, MA, USA, ou_persistent22              
11Department of Genetics, University of North Carolina (UNC), Chapel Hill, NC, USA, ou_persistent22              
12UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA, ou_persistent22              
13Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, ou_persistent22              
14LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, ou_persistent22              
15Inserm U1219, University of Bordeaux, Bordeaux University Hospital, Bordeaux, France, ou_persistent22              
16Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands, ou_persistent22              
17Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA, ou_persistent22              
18Faculty of Medicine, University of Iceland, Reykjavík, Iceland, ou_persistent22              
19Icelandic Heart Association, Reykjavík, Iceland, ou_persistent22              
20Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA, ou_persistent22              
21The University of Texas Health Science Center at Houston, Houston, TX, USA, ou_persistent22              
22Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK, ou_persistent22              
23Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria, ou_persistent22              
24Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria, ou_persistent22              
25Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
26Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
27Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
28GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
29Department of Neurology, Baylor College of Medicine, Houston, TX, USA, ou_persistent22              
30Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA, ou_persistent22              
31Department of Genetics, Harvard Medical School, Boston, MA, USA, ou_persistent22              
32Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, ou_persistent22              
33National Heart, Lung and Blood Institute’s Framingham Heart Study, Division of Intramural Research, Population Sciences Branch, Framingham, MA, USA, ou_persistent22              
34MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK, ou_persistent22              
35Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands, ou_persistent22              
36Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands, ou_persistent22              
37Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands, ou_persistent22              
38Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
39Centre for Brain Research, Indian Institute of Science, Bangalore, India, ou_persistent22              
40NORMENT - KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway, ou_persistent22              
41NORMENT - KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ou_persistent22              
42Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
43Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
44Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
45Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
46Max Planck Institute of Psychiatry, Munich, Germany, ou_persistent22              
47Mathematics and Statistics, Murdoch University, Perth, Australia, ou_persistent22              
48Lieber Institute for Brain Development, Baltimore, MD, USA, ou_persistent22              
49Department of Psychology, Yale University, New Haven, CT, USA, ou_persistent22              
50Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA, ou_persistent22              
51Biological Psychology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, ou_persistent22              
52Medical University of Lodz, Lodz, Poland, ou_persistent22              
53Department of Integrative Medical Biology, Umeå University, Umeå, Sweden, ou_persistent22              
54Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden, ou_persistent22              
55Department of Psychology, University of Oslo, Oslo, Norway, ou_persistent22              
56Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, ou_persistent22              
57Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, The Netherlands, ou_persistent22              
58Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada, ou_persistent22              
59The Royal College of Surgeons in Ireland, Dublin, ireland, ou_persistent22              
60Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands, ou_persistent22              
61Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK, ou_persistent22              
62Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland, ou_persistent22              
63Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, ou_persistent22              
64Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany, ou_persistent22              
65Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA, ou_persistent22              
66Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain, ou_persistent22              
67Department of Medicine, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain, ou_persistent22              
68CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain, ou_persistent22              
69Section for Experimental Psychopathology and Neuroimaging, Dept of General Psychiatry, Heidelberg University, Heidelberg, Germany, ou_persistent22              
70Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, ou_persistent22              
71Department of Radiology, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway, ou_persistent22              
72Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK, ou_persistent22              
73MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK, ou_persistent22              
74NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK, ou_persistent22              
75Department of Radiology, University of Calgary, Calgary, Canada, ou_persistent22              
76Department of Clinical Neurosciences, University of Calgary, Calgary, Canada, ou_persistent22              
77Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa, ou_persistent22              
78South African Medical Research Council (SAMRC) Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa, ou_persistent22              
79Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA, ou_persistent22              
80INSERM UMR 1000 ‘‘Neuroimaging and Psychiatry’’, University Paris-Sud, University Paris-Saclay, University Paris Descartes, Paris, France, ou_persistent22              
81Service Hospitalier Frédéric Joliot, Orsay, France, ou_persistent22              
82Maison de Solenn, Paris, France, ou_persistent22              
83Department of Neurology, Max Planck Institute of Cognitive and Brain Sciences, Leipzig, Germany, ou_persistent22              
84Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, Leipzig, Germany, ou_persistent22              
85International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
86Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_792549              
87Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
88German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany, ou_persistent22              
89Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA, ou_persistent22              
90Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA, ou_persistent22              
91Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA, ou_persistent22              
92Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA, ou_persistent22              
93Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria, ou_persistent22              
94QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
95Department of Pharmacology, National University of Singapore, Singapore, ou_persistent22              
96Memory Aging and Cognition Center, National University Health System, Singapore, ou_persistent22              
97Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA, ou_persistent22              
98Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
99Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia, ou_persistent22              
100National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia, ou_persistent22              
101Harvard Medical School, Boston, MA, USA, ou_persistent22              
102Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Lexington, MA, USA, ou_persistent22              
103Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, ou_persistent22              
104Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, MA, USA, ou_persistent22              
105Department of Psychiatry, University of Oxford, Oxford, UK, ou_persistent22              
106NIHR Dementia Biomedical Research Unit, King's College London, London, UK, ou_persistent22              
107NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway, ou_persistent22              
108Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway, ou_persistent22              
109Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark, ou_persistent22              
110Department of Biomedicine, Aarhus University, Aarhus, Denmark, ou_persistent22              
111The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark, ou_persistent22              
112Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
113Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden, ou_persistent22              
114UCL Institute of Neurology, London, UK, ou_persistent22              
115Epilepsy Society, Bucks, UK, ou_persistent22              
116Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia, ou_persistent22              
117Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia, ou_persistent22              
118Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
119Neuroimaging Unit,Technological Facilities Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain, ou_persistent22              
120Avera Institute for Human Genetics, Sioux Falls, SD, USA, ou_persistent22              
121Hospital for Sick Children, University of Toronto, Toronto, Canada, ou_persistent22              
122Center for Systems Neuroscience, Boston University, Boston, MA, USA, ou_persistent22              
123Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, ou_persistent22              
124Neurodegeneratives Diseases Institute, CNRS UMR 5293, Université de Bordeaux, Bordeaux, France, ou_persistent22              
125Pennington Biomedical Research Center, Los Angeles, CA, USA, ou_persistent22              
126Department of Adult Psychiatry, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ou_persistent22              
127NORMENT - KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway, ou_persistent22              
128Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK, ou_persistent22              
129Department of Computer Science, Lagos State University, Ojo, Nigeria, ou_persistent22              
130Queensland Brain Institute, University of Queensland, Brisbane, Australia, ou_persistent22              
131Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, ou_persistent22              
132Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
133Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia, ou_persistent22              
134Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
135Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
136Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA, USA, ou_persistent22              
137Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy, ou_persistent22              
138Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA, ou_persistent22              
139Department of Cognitive Sciences, University of California, San Diego, CA, USA, ou_persistent22              
140Department of Neurosciences, University of California, San Diego, CA, USA, ou_persistent22              
141Department of Psychiatry, University of California, San Diego, CA, USA, ou_persistent22              
142Department of Radiology, University of California, San Diego, CA, USA, ou_persistent22              
143Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland, ou_persistent22              
144Institute of Human Genetics, University of Bonn, Bonn, Germany, ou_persistent22              
145Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany, ou_persistent22              
146Reta Lila Weston Institute, UCL Institute of Neurology, London, UK, ou_persistent22              
147Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK, ou_persistent22              
148Department of ECE, University of New Mexico, Albuquerque, NM, USA, ou_persistent22              
149The Mind Research Network & LBERI, Albuquerque, NM, USA, ou_persistent22              
150Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada, ou_persistent22              
151Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada, ou_persistent22              
152FC Donders Centre for Cognitive Neuroimaging , External Organizations, ou_55235              
153Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany, ou_persistent22              
154Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
155Department of Pediatrics, VU Medical Center, Amsterdam, The Netherlands, ou_persistent22              
156Emma Children's Hospital Amsterdam Medical Center, Amsterdam, The Netherlands, ou_persistent22              
157Univ. Lille, Inserm, Centre Hosp. Univ Lille, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Lille, France, ou_persistent22              
158RID-AGE - Risk factors and molecular determinants of aging-related diseases, Epidemiology and Public Health Department, Lille, France, ou_persistent22              
159Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
160Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center,, Torrance, CA, USA, ou_persistent22              
161Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, CA, USA, ou_persistent22              
162Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia, ou_persistent22              
163Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia, ou_persistent22              
164Dementia Collaborative Research Centre - Assessment and Better Care, UNSW, Sydney, Australia, ou_persistent22              
165Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece, ou_persistent22              
166Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, ou_persistent22              
167Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, The Netherlands, ou_persistent22              
168Department of Molecular and Cellular Therapeutics, the Royal College of Surgeons in Ireland, Dublin, Ireland, ou_persistent22              
169Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, ou_persistent22              
170Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands, ou_persistent22              
171Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia, ou_persistent22              
172Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
173Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands, ou_persistent22              
174Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
175NORMENT - KG Jebsen Centre for Psychosis Research, Department of Psychology, University of Oslo, Oslo, Norway, ou_persistent22              
176Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK, ou_persistent22              
177Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA, USA, ou_persistent22              
178University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany, ou_persistent22              
179Brain and Mind Centre, University of Sydney, Sydney, Australia, ou_persistent22              
180Neuroscience Research Australia, Sydney, Australia, ou_persistent22              
181University of New South Wales, Sydney, Australia, ou_persistent22              
182Department of Internal Medicine, INSERM U 558, University of Toulouse, Toulouse, France, ou_persistent22              
183Department of Geriatric Medicine, INSERM U 558, University of Toulouse, Toulouse, France, ou_persistent22              
184Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany, ou_persistent22              
185Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA, ou_persistent22              
186Neurology Division, Beaumont Hospital, Dublin, Ireland, ou_persistent22              
187Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, ou_persistent22              
188Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, CA, USA, ou_persistent22              
189Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California Davis, Davis, CA, USA, ou_persistent22              
190Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, ou_persistent22              
191KG Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway, ou_persistent22              
192Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
193Kaiser Permanent Washington Health Research Institute, Seattle, WA, USA, ou_persistent22              
194Cardiovascular Health Research Unit, Department of Epidemiology and Health Services, University of Washington, Seattle, WA, USA, ou_persistent22              
195Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
196Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, Sydney, Australia, ou_persistent22              
197Biomedical Research Unit for Dementia, King's College London, London, UK, ou_persistent22              
198Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK, ou_persistent22              
199Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
200Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA, ou_persistent22              
201Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA, ou_persistent22              
202Department of Radiology, Mayo Clinic, Rochester, MN, USA, ou_persistent22              
203School of Medical Sciences, UNSW, Sydney, Australia, ou_persistent22              
204Department of Biomedicine, University of Basel, Basel, Switzerland, ou_persistent22              
205Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA, ou_persistent22              
206Translational Genomics Research Institute, Neurogenomics Division, Phoenix, AZ, USA, ou_persistent22              
207Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, ou_persistent22              
208Radiation Sciences, Umeå University, Umeå, Sweden, ou_persistent22              
209Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              
210Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, ou_persistent22              
211Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
212Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
213Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
214Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
215Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands, ou_persistent22              
216Institut Pasteur, Paris, France, ou_persistent22              
217Department of Neurology, University of Washington, Seattle, WA, USA, ou_persistent22              
218Department of Epidemiology, University of Washington, Seattle, WA, USA, ou_persistent22              
219Neuroimaging Centre, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
220Rotman Research Institute, University of Toronto, Toronto, Canada, ou_persistent22              
221Max Planck Institute for Human Cognitive and Brain Sciences and Clinic for Cognitive Neurology, University Clinic Leipzig, Leipzig, Germany, ou_persistent22              
222HMNC Brain Health, Munich, Germany, ou_persistent22              
223Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium, ou_persistent22              
224Department of Psychology, Georgia State University, Atlanta, GA, USA, ou_persistent22              
225Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
226Department of Medical Genetics, Oslo University Hospital, Oslo, Norway, ou_persistent22              
227Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ou_persistent22              
228Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, ou_persistent22              
229Institute of Translational Medicine, University of Liverpool, Liverpool, UK, ou_persistent22              
230Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland, ou_persistent22              
231Neurocentre Neurology, Kuopio University Hospital, Kuopio, Finland, ou_persistent22              
232Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
233German Center for Cardiovascular Research (DZHK eV), Greifswald, Germany, ou_persistent22              
234Department of Neuroinformatics, Araya, Inc., Tokyo, Japan, ou_persistent22              
235Institute of Cognitive Neuroscience, University College London, London, UK, ou_persistent22              
236School of Psychology, University of Sussex, Brighton, UK, ou_persistent22              
237Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
238Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands, ou_persistent22              
239Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands, ou_persistent22              
240GROW School for Oncology and Developmental Biology, Maastricht, The Netherlands, ou_persistent22              
241Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany, ou_persistent22              
242Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia, ou_persistent22              
243Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              
244Department of Psychology, VU University Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
245Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, CA, USA, ou_persistent22              
246Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA, ou_persistent22              
247Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands, ou_persistent22              
248The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA, ou_persistent22              
249Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA, ou_persistent22              
250UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK, ou_persistent22              
251Department of Neurology, Center for Neuroscience, University of California at Davis, Sacramento, CA, USA, ou_persistent22              
252Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA, ou_persistent22              
253Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital,, Houston, TX, USA, ou_persistent22              
254Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA, ou_persistent22              
255Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA, ou_persistent22              
256Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA, ou_persistent22              

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 Abstract: Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

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Language(s): eng - English
 Dates: 20192019-10-212019-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41588-019-0511-y
 Degree: -

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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 51 Sequence Number: - Start / End Page: 1624 - 1636 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609