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  Interleaving motor sequence training with high-frequency rTMS facilitates consolidation

Rumpf, J.-J., May, L., Fricke, C., Classen, J., & Hartwigsen, G. (2020). Interleaving motor sequence training with high-frequency rTMS facilitates consolidation. Cerebral Cortex, 30(3): bhz145, pp. 1030-1039. doi:10.1093/cercor/bhz145.

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 Creators:
Rumpf, Jost-Julian1, Author
May, Luca2, Author
Fricke, Christopher1, Author
Classen, Joeph1, Author
Hartwigsen, Gesa2, Author           
Affiliations:
1Department of Neurology, University of Leipzig, ou_persistent22              
2Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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Free keywords: Motor learning; Motor consolidation; Transcranial magnetic stimulation; Primary motor cortex; Training
 Abstract: The acquisition of novel motor skills is a fundamental process of lifelong learning and
crucial for everyday behaviour. Performance gains acquired by training undergo a
transition from an initially labile state to a state that is progressively robust towards
interference, a phenomenon referred to as motor consolidation. Previous work has
demonstrated that the primary motor cortex (M1) is a neural key region for motor
consolidation. However, it remains unknown whether physiological processes
underlying post-training motor consolidation in M1 are active already during an
ongoing training phase or only after completion of the training. We examined whether
10 Hz interleaved repetitive transcranial magnetic stimulation (i-rTMS) of M1 during
rest periods between active motor training in an explicit motor learning task affects
post-training offline consolidation. Relative to i-rTMS to the vertex (control region), irTMS
to the M1hand area of the non-dominant hand facilitated post-training
consolidation assessed 6 hours after training without affecting training performance.
This facilitatory effect generalized to delayed performance of the mirror-symmetric
sequence with the untrained (dominant) hand. These findings indicate that posttraining
consolidation can be facilitated independently from training-induced
performance increments and suggest that consolidation is initiated already during
offline processing in short rest periods between active training phases.

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Language(s): eng - English
 Dates: 2019-05-242019-03-252019-06-112019-08-022020-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/cercor/bhz145
PII: bhz145
PMID: 31373620
 Degree: -

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Funding organization : Max Planck Society
Project name : -
Grant ID : HA 6314/3-1 ; HA 6314/4-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 30 (3) Sequence Number: bhz145 Start / End Page: 1030 - 1039 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440