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  Interleaving motor sequence training with high-frequency rTMS facilitates consolidation.

Rumpf, J.-J., May, L., Fricke, C., Classen, J., & Hartwigsen, G. (2019). Interleaving motor sequence training with high-frequency rTMS facilitates consolidation. Cerebral Cortex. doi:10.1093/cercor/bhz145.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C8FF-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-711E-C
Genre: Journal Article

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 Creators:
Rumpf, J.-J.1, Author
May, L.2, Author
Fricke, C.1, Author
Classen, J.1, Author
Hartwigsen, Gesa2, Author              
Affiliations:
1Department of Neurology, University of Leipzig, ou_persistent22              
2Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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Free keywords: motor learning; motor consolidation; transcranial magnetic stimulation; primary motor cortex; training
 Abstract: The acquisition of novel motor skills is a fundamental process of lifelong learning and crucial for everyday behaviour. Performance gains acquired by training undergo a transition from an initially labile state to a state that is progressively robust towards interference, a phenomenon referred to as motor consolidation. Previous work has demonstrated that the primary motor cortex (M1) is a neural key region for motor consolidation. However, it remains unknown whether physiological processes underlying post-training motor consolidation in M1 are active already during an ongoing training phase or only after completion of the training. We examined whether 10 Hz interleaved repetitive transcranial magnetic stimulation (i-rTMS) of M1 during rest periods between active motor training in an explicit motor learning task affects post-training offline consolidation. Relative to i-rTMS to the vertex (control region), irTMS to the M1hand area of the non-dominant hand facilitated post-training consolidation assessed 6 hours after training without affecting training performance. This facilitatory effect generalized to delayed performance of the mirror-symmetric sequence with the untrained (dominant) hand. These findings indicate that posttraining consolidation can be facilitated independently from training-induced performance increments and suggest that consolidation is initiated already during offline processing in short rest periods between active training phases.

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 Dates: 2019-05-242019-03-252019-06-112019-08-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhz145
PII: bhz145
PMID: 31373620
Other: Epub ahead of print
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Funding organization : Max Planck Society
Project name : -
Grant ID : HA 6314/3-1 ; HA 6314/4-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440