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  Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

Escobedo-Ruíz, A., Barquera, R., González-Martín, A., Millán, J.-M.-A.-S., Uribe-Duarte, M. G., Hernández-Zaragoza, D. I., et al. (2019). Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California. Human Immunology, 2019.06.007. doi:10.1016/j.humimm.2019.06.007.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C7C6-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-A152-7
Genre: Journal Article

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Escobedo-Ruíz, Araceli, Author
Barquera, Rodrigo1, Author              
González-Martín, Antonio, Author
Millán, Juan Manuel Argüelles-San, Author
Uribe-Duarte, María Guadalupe, Author
Hernández-Zaragoza, Diana Iraíz, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
de Ruíz-Corral, María Jesús, Author
Goné-Vázquez, Isis, Author
Arellano-Prado, Francia Paulina, Author
Martínez-Álvarez, Julio César, Author
García-Arias, Víctor Eduardo, Author
Rodríguez-López, Marla Estefanía, Author
Bravo-Acevedo, Alicia, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Aguilar-Campos, Jesús Abraham, Author
Gómez-Navarro, Benjamín, Author
Sandoval-Sandoval, Mario J., Author
Serrano-Osuna, Ricardo, Author
Yunis, Edmond J., AuthorZúñiga, Joaquín, AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Baja California, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84 by ML; 42.03 of European haplotypes) and Native American (43.72 ± 2.36 by ML; 40.24 of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98 by ML; 9.36 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-11
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.007
Other: shh2255
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: 2019.06.007 Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912